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Eliminating Problems in Drug Development: Understanding the Role of Drug Metabolism

Presenter: Andrew G. Taylor, Ph.D., Manager of Technical Support for Services at SEKISUI XenoTech

This talk will discuss processes for the metabolism of a drug, referred to as ADME (Absorption, Distribution, Metabolism, Excretion), and the safety testing to provide requisite information to move a drug through IND and into clinical trials. Prior to marketing a new drug and actually prior to administering a candidate drug to humans in clinical trials, it is important to ensure that drug will not only be effective in the therapeutic manner prescribed, but also be safe and not bring any undo harm to patients. How a drug is metabolized is one of the most important aspects to understand. If you are involved in the development of potential new therapeutics, this discussion will help you gain necessary knowledge to inform your drug development decisions.

Key concepts discussed in this webinar will include:
- The overarching aim of therapeutic drug development
- DMPK – Drug metabolism and pharmacokinetics
- Based on ADME properties
- Relationship to Drug-Drug Interactions (DDI)
- ADME properties
- Predominant types of in vitro ADME & Drug-Drug Interaction (DDI) studies
- Why run these studies?
- When to conduct these studies
- Areas of concern: Proper design & interpretation

Download a copy of the slides: https://www.xenotech.com/wp-content/uploads/2021/09/SEKISUI-XenoTech-Eliminating-Problems-in-Drug-Development-Understanding-the-Role-of-Drug-Metabolism.pdf
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About the Presenter:
Dr. Andrew G. Taylor received his Ph.D. from University of California San Diego, Scripps Institution of Oceanography. He joined SEKISUI XenoTech as a research scientist in 2017, serving as a Study Director in nonclinical drug interaction contract studies compliance with Good Laboratory in Practices (GLP), OECD Principles of GLP, &/or Japan MOHW GLP Standards and specializing in drug transport and drug metabolism studies. He became the Technical Support Manager for services in 2020 and provides valuable guidance to ensure research needs are being met.