Expanding Possibilities for Compound Library Generation in Flow with Immobilized and Exchangeable Reagents

Video   Apr 29, 2016

 


About the Speaker
Noah Tu is a Senior Scientist with Discovery Chemistry and Technology at AbbVie Inc in North Chicago, Illinois. Noah has over 20 years of experience in the pharmaceutical industry. He joined Abbott Laboratories as a medicinal chemist in 1994 after graduating from University of Victoria in Canada. In 2000 Noah established the High Throughput Organic Synthesis group in Abbott Laboratories for compound library synthesis. In 2002 Noah joined S*BIO, a startup company in Singapore, and established the High Throughput Synthesis and Analytic group. Noah rejoined Abbott/AbbVie in 2006 and has pioneered in the setup of several novel integrated synthesis-purification systems for rapid compound library generation.
AbstractA custom-built modular flow reactor featuring immobilized reagents in exchangeable cartridges has been developed. The concept is based on a custom designed flow reactor with easy access to internal components for reagent cartridge exchange. Custom made reagent cartridges filled with different supported catalysts and reagents are used for various reaction conditions. The custom reactor has, as one component, the same footprint as the Accendo ConjureTM reactor and no hardware or software modification to the Conjure unit is required. This reactor opens the way to chemical transformations previously not readily achievable with Accendo Conjure flow chemistry system. In this presentation, we demonstrate the applicability of this system to tandem Click-Suzuki reactions.

 
 
 
 

Recommended Videos

Blood, Rats and Anticoagulants: The Story of Warfarin

Video

The history of warfarin, one of the earliest anticoagulant drugs, is littered with the bodies of sick cows and poisoned rats. This animation tells the story of how a bloody beginning gave rise to a life-saving medication.

WATCH NOW

Introduction to Peptides and Proteins for Bioanalysis Using LC-MS

Video

Khalid Khan, Senior Manager Business Development, discusses the basic structure of amino acids, peptides, and proteins, including specific examples like monoclonal antibodies. The ionization and fragmentation of peptides and how they differ from small molecules is also discussed.

WATCH NOW

Solutions for High-Throughput and Phenotypic Screening

Video

Accelerate drug discovery workflows with state-of-the art imaging and detection instruments, assay technologies, reagents, versatile automation systems, and powerful informatics solutions that work together to ensure consistent, accurate, physiologically relevant results. Wrest more meaning from your findings with PerkinElmer's one-of-a-kind analytics, and amplify your phenotypic or target-based screens to identify hits and lead compounds in small and focused or high-throughput volumes.

WATCH NOW

 

Comments | 0 ADD COMMENT

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE