We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Advertisement

Putting a Human Heart & Fat on a Chip

Video   Oct 19, 2016

 

Drug discovery and development to date has relied on animal models, which are useful, but fail to resemble human physiology. The discovery of human induced pluripotent stem (iPS) cells has led to the emergence of a new paradigm of drug screening using human disease-specific organ-models. One promising approach to produce these systems is employing microfluidic devices, which can simulate 3D tissue structure and function. Using microfabrication techniques we have developed two microphysiological platforms (MPSs) that incorporate in vitro models of human cardiac and adipose tissue. Both MPSs consist of three functional components: a tissue culture chamber mimicking geometrical organ-specific in vivo properties; “vasculature-like” media channels enabling a precise and computationally predictable delivery of compounds (nutrients, drugs); “endothelial-like” barriers protecting the tissues from shear forces while allowing diffusive transport. Both organ-chips are able to create physiological micro-tissues that are viable and functional for multiple weeks. The developed chips are the first systems that combine human genetic background, physiologically relevant tissue structure and “vasculature-like” perfusion. Pharmacological studies on the heart-chip show IC50/EC50 values more consistent with data from primary tissue references compared to cellular scale studies. Both MPSs are extremely versatile and can be applied for drug toxicity screening and fundamental research.

 
 
 
Advertisement
 

Recommended Videos

TSE Explores Drug Discovery – Testing a Drug Compound: Clinical Trials

Video

In this episode we speak with Dr Stephen Wright, Consultant in Medicines Development from Limber Strategic, who talks to us about the clinical development of a drug, including how clinical trials are designed and the role of regulatory authorities in the process.

WATCH NOW

TSE Explores Drug Discovery – Identifying and Optimizing a Promising Drug

Video

In this episode we speak with Professor Paul Brennan from the University of Oxford about lead optimization, what to consider when designing a new drug, and much more.

WATCH NOW

TSE Explores Drug Discovery – How Are Drugs Developed?

Video

In this episode, we speak with Tomasz Kostrzewski, Director of Biology at CN Bio about how drugs are developed, including the challenges faced when designing and developing a drug, how drug discovery has evolved, and what trends we can expect to see in the future.

WATCH NOW

 

To personalize the content you see on Technology Networks homepage, Log In or Subscribe for Free

LOGIN SUBSCRIBE FOR FREE