How Cells Know They’re Infected With SARS-CoV-2 and How the Subsequent Response to This Results in COVID-19
Who's speaking at this Webinar?
Benjamin tenOever, Ph.D.
Fishberg Professor of Medicine, Director, Virus Engineering Center for Therapeutics and Research (VECToR) Icahn School of Medicine at Mount Sinai
Almost every cell of the 30 trillion that comprise the human body has the capacity to recognize when they are infected with a virus.
Once aware of this threat, the infected cell has two main responsibilities. First, the cell must launch a call to arms.
This task requires the secretion of a signal (interferon) that informs the surrounding cells of the imminent threat and instructing them to fortify their defences.
The second responsibility is to launch a call for reinforcements. This task also requires a secreted signal (chemokines) that recruits more sophisticated immune cells to the site of infection.
Attendees will learn how
- Host cells detect the presence of SARS-CoV-2
- The host immune response dynamics play out in response to SARS-CoV-2
- SARS-CoV-2 blocks only aspects of the host cellular response
- Interactions between the virus and host ultimately result in COVID-19