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Identify and Quantify Individual Host Cell Proteins

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Identify and Quantify Individual Host Cell Proteins
 
Dr Thomas Kofoed
CEO Alphalyse
 

ELISA is the golden standard for HCP analysis but has some drawbacks. It only provides a single number (ng HCP/mg drug substance) and no information about the specific HCP’s.

Here we present an HCP analysis method based on a SWATH LC-MS that provides reproducible identification and absolute quantification of each individual HCP as well as the total HCP content. The method is generic for vaccines, mAbs, small therapeutic proteins and protein biopharmaceuticals expressed in different cell lines and expression systems.

Learn how SWATH™ enables:

The Identification and quantification of individual host cell protein
The evaluation of ELISA assays for analysis of host cell protein.
Bioprocess optimization for removal of process impurities in expressed in different cell lines and expression systems.


 
 
 
 

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