Insights Into the Acute Central Nervous System Responses to Oligonucleotide Delivery
Want to share this FREE webinar with a colleague?
Fill out the form below and we'll send your colleague an invitation to the "Insights Into the Acute Central Nervous System Responses to Oligonucleotide Delivery" event.
Understanding and managing acute central nervous system (CNS) effects is essential when developing therapeutic oligonucleotides. Recent research reveals two transient CNS responses following intrathecal administration – rapid neuronal activation and delayed, reversible sedation – each driven by distinct factors such as dose, sequence and chemical composition. Standardized behavioral frameworks now enable consistent evaluation across species, helping researchers interpret neurotoxic responses more effectively.
Join this webinar to explore how these insights can improve assessment of safety and tolerability in oligonucleotide-based therapies targeting the CNS.
Attend this webinar to:
- Understand the nature of two distinct reversible adverse effects that can occur immediately after central administration of antisense oligonucleotides (ASOs)
- Learn how to evaluate these neurotoxicity profiles in rodents
- Explore strategies to mitigate immediate ASO-induced toxicity
Brought to you by
Have a question about our online events and webinars?
Get in touch here.
Now Available on Demand!
Information you provide will be shared with the sponsors for this content. Technology Networks or its sponsors may contact you to offer you content or products based on your interest in this topic. You may opt-out at any time.
Experiencing issues viewing the form? Click here to access an alternate version
