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Illustration of two therapeutic antibodies (blue) binding to receptors on a cell membrane (orange), blocking cellular pathways.

Monitor Protein Therapeutic Color Changes With LC-MS

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The color of a therapeutic monoclonal antibody solution is a critical quality attribute (CQA), essential for maintaining consistency throughout clinical trials and commercial production. 


Color changes are often associated with advanced glycation end products (AGEs), which form as post-translational modifications (PTMs). Monitoring these changes is essential, as they can impact both the efficacy and safety of the final drug product.


This webinar explores the implementation of a liquid chromatography-mass spectrometry (LC-MS) workflow for peptide mapping to investigate and track these PTMs.


Watch this webinar to explore:

    • Key product quality attributes associated with color changes in therapeutics
    • The connection between AGEs and color variation
    • The use of LC-MS to quantitatively monitor AGEs in drug development
    Keynote Speaker
    A picture of Andrew D. Mahan, PhD
    Andrew D. Mahan, PhD
    Mass Spec Group Leader, Cell Engineering and Analytical Sciences
    J&J Innovative Medicines
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