Identifying Oligonucleotide Impurities and Metabolites With High-Resolution Mass Spectrometry
With the rapid increase in the development of oligonucleotide therapeutics and gene therapies, workflows for the identification, characterization and quantification of full-length products, their impurities and metabolites, are critical.
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability (PHATHOM)
Psychedelics have been used for millennia in both spiritual and medicinal contexts. Recently, a number of clinical successes with psychedelics have generated considerable excitement; nevertheless, mechanisms underlying their therapeutic efficacy are largely unknown.
Bringing Life to PK Profiles – In Vivo-Relevance From an In Vitro Environment
In drug development, microphysiological systems (MPS) are utilized to develop in vitro biological models that can generate more physiologically- and human-relevant data.
Racing Against Time: Rapid, High-Throughput Discovery of Antibody Therapeutics for SARS-CoV-2
Vanderbilt University Medical Center researchers Robert Carnahan and Pavlo Gilchuk are attempting to compress the timeline for therapeutic antibody development, by integrating a series of advances in single-cell messenger RNA sequence analysis, bioinformatics, synthetic biology and high-throughput functional analysis.
How To Stop Good Pharmaceutical Formulations Going Bad
Selection of the appropriate techniques and assays, and their application in well-managed analytical programs, can simplify the process of deformulation and ensure a speedy route to market.
Handheld FTIR Measurement of Surface Contamination
Surface contamination can be a major problem within many industries. It has been shown to lead to component failures, production issues, final product defects and often expensive warranty claims.