Cell Painting – Phenotypic Drug Discovery Re-Imagined
Cell Painting is a multistep process, in which different compartments of cells are labeled with various fluorescent bioprobes to quantitatively profile multiple phenotypic parameters to better understand the effects of chemical compounds, drugs, genes, or other test articles.
PD-1/PD-L1 Combination Therapy in Cancer Treatment
Cancer immunotherapy, especially the use of immune checkpoint inhibitors, has been successful in improving the treatment landscape of malignancies.
High-Throughput, Multi-Parametric Analysis Accelerates Antibody Discovery Workflows
Download this whitepaper to discover how high-throughput flow cytometry can provide quantitative data on binding, antibody internalization and antibody-dependent cell-mediated cytotoxicity, antibody-dependent cellular phagocytosis and T-cell activation.
Respiratory Syncytial Virus Antigens and Antibodies
Respiratory syncytial virus (RSV) has a high mortality rate and is the leading cause of lower respiratory tract infections in children and infants worldwide.
Key Trends in Lab Automation 2022
Despite the increasing adoption of lab automation in the sciences, in 2022, awareness about what it can truly do remains frustratingly limited, with most labs mistaking partial automation to mean a lab is fully automated, and other labs with fully integrated automation systems losing out on flexibility.
Improving Efficiency in Drug Discovery and Preclinical Development
Creating and bringing new drugs to the market can bring huge productivity challenges as the already complex drug development process becomes lengthier and more expensive.
Automation of High-Throughput Flow Cytometry
Historically, limited color detection, large sample volumes and manual loading were the reality of flow cytometers. Today however, flow cytometers can detect dozens of colors/markers simultaneously, saving precious samples and speeding up processing time.
New for Old: The Value of Transitioning from qPCR to ddPCR
Droplet Digital PCR (ddPCR) is a refined form of digital PCR that offers a scalable and practical method for the absolute quantification of nucleic acids. 2021 marks ten years since the advent of ddPCR and in that time it has revolutionized discovery, development and quality control of biopharmaceuticals such as antibody-based biologics, vaccines, and cell and gene therapies.
Critical Parameters for Cleanroom Monitoring
Validation is an important process to ensure cleanrooms meet specific standards to be classified according to the International Standards Organization (ISO). ISO classifications ensure the integrity of the products, ranging from pharmaceuticals to semiconductors, contained in the cleanroom.
Can Your Clinical Diagnostics Contract Manufacturer Weather Supply Chain Challenges?
Supply chain security and transparency is a key part of the risk mitigation strategy of companies manufacturing clinical diagnostic assays. Prior to the COVID-19 crisis, complex global supply chains carefully balanced capacity with demand while cost-cutting initiatives pushed towards lower cost raw material providers located in different geographies.