Carbonylation using carbon monoxide: Novasep’s shortcut to complex structures

The rising complexity of active pharmaceutical ingredients (APIs), combined with the need to curb costs, calls for creative solutions. The use of highly reactive reagents in the synthesis routes offers an important extension of the existing traditional chemical processes for pharmaceutical, agrochemical and specialty chemical companies. These potentially hazardous reactions often substantially shorten the synthesis routes while at the same time affording highly selective individual reactions.

However, such high reactivity also involves a certain hazard potential, leading to certain reservations regarding their use, in spite of the technical and commercial benefits they offer. But, when handled and controlled by experts, hazardous chemistry represents an indispensible supplement to synthesis technology.

This white paper details carbonylation employed by Novasep to synthesise APIs and advanced intermediates for the pharmaceutical, crop science and other fine chemical industries.