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How to Choose the Right Assay for PARP

How to Choose the Right Assay for PARP
Credit: iStock

Poly ADP-ribose polymerases (PARPs) are involved in a wide range of biological functions from DNA damage repair to gene expression regulation. As a result, PARPs are therapeutic targets for cancer, with several PARP inhibitors approved for clinical use and others in development to circumvent therapeutic resistance issues.

When assessing PARP enzymatic activity for drug development, each component must be carefully optimized to ensure sensitivity, robustness and reproducibility. This whitepaper explores methods and reagents available to evaluate drug specificity and effectiveness.

Download this whitepaper to explore:

  • Robust assays to quantify PARP interactions for drug discovery
  • Key considerations when choosing an assay format
  • Custom services and kits to support your research needs


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