Investigating Cell-Free DNA in Liquid Biopsy
Only a small amount of cell-free DNA (cfDNA) can be found in circulation, therefore efficient and highly sensitive technologies such as next-generation sequencing (NGS) are typically being used to detect this biomarker.
However, NGS is not without its challenges. If genomic DNA is released from lysed or apoptotic cells, this can contaminate the cfDNA in the sample.
This whitepaper discusses the challenges and opportunities in measuring cfDNA from liquid samples.
Download this whitepaper to learn more about:
- Limitations of a tissue biopsy
- The challenges and advantages of using cfDNA
- How library preparation has advanced to tackle sample bottlenecks