The physical components and features of an Isothermal Titration Calorimeter (ITC) instrument and the technical specifications are clearly important to consider when purchasing a new system. However, written specifications can be confusing, misleading and may actually have very little bearing on the actual performance of the instrument. Specifications, on paper, do not necessarily translate into advantages or disadvantages when it comes to making measurements on your samples. 

Here are some questions you should ask yourself as you begin evaluating isothermal titration calorimeters.