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10 Things We Didn't Know Last Week, September 21, 2018

List

10 news stories from across the world of science guaranteed to make you sound more interesting

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Biomarkers and the Future of Precision Medicine

Blog

Biomarkers hold immense potential for the future of medicine, enabling more efficient and better-targeted treatments. Most coverage of novel biomarkers to date has been focused on how a patient’s genetic signature can indicate their susceptibility to a disease, but there is a world of other biological and environmental information that can impact how patients respond to treatments. In this blog, SCIEX’s Aaron Hudson explains how non-genetic biomarkers have a key role to play in reaching the goal of truly precise medicine.

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NGS Workflows: A Simpler Life Through Software

Blog

Having too much data sounds like a nice problem to have. But Next Generation Sequencing (NGS) data’s ubiquity poses challenges as well as opportunities for geneticists. Quick, accurate and reliable workflows are top of the average geneticist’s wishlist. We caught up with OGT’s Dave Cook to discuss the challenges of NGS data, and how software can make things simpler.

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DNA Traces Illegal Ivory Shipments Back to Major Cartels

DNA Traces Illegal Ivory Shipments Back to Major Cartels

News

The international trade in elephant ivory has been illegal since 1989, yet African elephant numbers continue to decline. A study reports that DNA test results of ivory seizures made by law enforcement have linked multiple ivory shipments to the same network of dealers operating out of a handful of African ports.

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Epigenetic Signature May Help People Stay Ahead of IBD
News

In treating inflammatory bowel disease (IBD), physicians can have a hard time telling which newly diagnosed patients have a high risk of severe inflammation or what therapies will be most effective. Now researchers report finding an epigenetic signature in patient cells that appears to predict inflammation risk in a serious type of IBD called Crohn’s disease.

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Decoding the Structure of an RNA-Based CRISPR System
News

Over the past several years, CRISPR-Cas9 has moved beyond the lab bench and into the public zeitgeist. Now, scientists from the Salk Institute are reporting for the first time the detailed molecular structure of CRISPR-Cas13d, a promising enzyme for emerging RNA-editing technology.

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Unprecedented View of Gene Therapy Virus
News

Using cryo-electron microscopy, scientists have obtained an unprecedented view of a gene-delivery virus, paving the way for further development of improved gene therapies.

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Three Ways to Turn Life Science Suppliers into Partners
Three Ways to Turn Life Science Suppliers into Partners
Article

A growing number of life science businesses are turning to greater supply chain collaboration for benefits like accelerated time to market, improved quality, reduced risk and more rapid and widespread innovation. But while 68% of executives in this industry say active and meaningful engagement with suppliers is essential to success, far too many, over a third, struggle to implement it.

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Lytic vs Lysogenic – Understanding Bacteriophage Life Cycles
Lytic vs Lysogenic – Understanding Bacteriophage Life Cycles
Article

Bacteriophage (phage) are obligate intracellular viruses that specifically infect bacteria. Here we take an overview of their structure, life-cycle and the role they have played in advancing science and medicine.

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Microbiome Medicine Takes Center Stage
Microbiome Medicine Takes Center Stage
Article

Personalized medicine isn’t all about our DNA. Researchers are increasingly looking past the information encoded on our genes to find answers to how individual variation contributes to complex disease. Companies like the Cambridge-based Microbiotica are much more interested in the bacterial cells that live inside us; our microbiome.

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Studying the Genome One Cell at a Time
Studying the Genome One Cell at a Time
Article

In 2013, Nature named single-cell sequencing (SCS) as the ‘Method of the Year’, citing its potential to transform the fields of biology and medicine. Now, the technique is bringing to light how genetic information can change between individual cells and facilitating the study of rare cell types. This article explores how these insights have helped scientists understand how diseases like cancer can evolve and spread in humans.

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The Agricultural Perspective on Water Contamination by Pharmaceuticals
The Agricultural Perspective on Water Contamination by Pharmaceuticals
Article

Despite centuries of research into drug development, investigation into the environmental impact of pharmaceuticals is a much younger field. If not treated effectively, there is the potential for pharmaceuticals in wastewater to affect the agricultural industry through the use of this contaminated water supply.

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Genome Editing and Human Reproduction: Behind the Headlines of the Nuffield Council on Bioethics Report
Genome Editing and Human Reproduction: Behind the Headlines of the Nuffield Council on Bioethics Report
Article

Two weeks ago, the Nuffield Council on Bioethics released a seminal report on the social and ethical issues of heritable genome editing. In an article written exclusively for Technology Networks, Hugh Whittall, Director of the Council, looks in-depth at the conclusions and implications of the Council's report.

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