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Tips for PCR primer design

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Simple yet useful tips on how to design good primers for PCR reactions and what to avoid!

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Scientists Take Action To Stop Gender Inequality and Sexual Harassment in STEM

Article

In December 2018, a diverse group of scientific researchers gathered to challenge a key issue in the science, technology, engineering and mathematics (STEM) workforce: gender bias, and sexual harassment. Now, the conclusions from the meeting have been eloquently described by 23 authors in an article published in the journal Science.

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Deep Learning Helps Tease Out Gene Interactions
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Convolutional neural networks could be used to help identify disease-related genes and genetic pathways that could be targets for drugs.

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How To Hide Data in Everyday Objects
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Researchers have developed a means of storing extensive information in almost any object. The way of storing this information is the same as for living things: in DNA molecules.

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Gut Feeling: A Network-based Approach Towards Understanding IBD
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Scientists have discovered how to get detailed transcriptomics data from gut organoids, and regulatory networks to analyze them, establishing a pipeline that can be used to explore the causes of inflammatory bowel disease.

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Increasing Food Intake by Swapping Mitochondrial Genomes
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To uncover the relationship between variation in genes and phenotypic diversity, geneticists use a set of fully sequenced fruit-fly genomes. But little is known about the variation in the mitochondrial genome, for which mutations are linked to an array of diseases. Now, EPFL scientists have created a high-resolution map of mitochondrial DNA variants in the fruit fly, connecting mitochondrial genes to metabolic traits and diseases.

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Bacteria Detox Using RNAs
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Using a new technique, NAIL-MS, researchers have discovered a novel type of chemical modification in bacterial RNAs. The modification is apparently attached to molecules only when cells are under stress, and is rapidly removed during recovery.

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The Role of Genetics in Sight and Preventing Blinding Eye Diseases
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Researchers have discovered unique patterns of genetic activity that could lead to development of blinding retinal diseases.

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Scream If You Wanna Go FASTA: Breaking the Bottleneck in Genomic Data Analysis
Article

In the post-genomic era, the direct cost associated with performing sequencing reactions has diminished, whereas the data processing, storage, management, and interpretation costs have increased exponentially. In this article, we explore how new tools are simplifying the process of genomic data analysis.

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Scientists Left Perplexed at Latest Alzheimer’s Drug Data
Article

In this article, we revisit the many twists and turns of the aducanumab clinical trials and explore the scientific community's response to the latest analysis of the data.

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Advances in PCR Diagnostics for Cancer and Medical Mycology
Article

From detecting cancer to microbial infections, and now even fungal infections, PCR has become the gold standard of analyzing gene expression. In this article, we explore how PCR is used as a novel diagnostic strategy to identify clinically important yeast species, as well as to detect mutations that could guide therapeutic decisions for lung cancer patients.

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Key Themes and Conversations From the First Lab of the Future Congress
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What do we mean by lab of the future? What innovations are required to get there? These are the key themes explored by this year's Lab of the Future Congress, summarized in this article.

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Technology Networks Explores the CRISPR Revolution: An Interview With Professor Glenn Cohen, World-leading Expert on Bioethics
Article

In this feature of Technology Networks Explores the CRISPR Revolution, we interview Professor Glenn Cohen, director of Harvard Law School's Petrie-Flom Center for Health Law Policy, Biotechnology and Bioethics.

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Metabolomics: A “Go-to” Approach in Systems Biology
Article

The measurement of low-molecular-weight metabolites and their intermediates reflects the dynamic response of the body to physiological, pathophysiological and developmental stimulus (e.g., aging). In this article, we explore how metabolomic profiling is advancing an array of scientific disciplines, including medicine and agriculture.

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