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CRISPR in Drug Combination Discovery

Video

Dr David Sorrell, Horizon Discovery, explains how CRISPR is used in drug combination discovery.

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PromethION in action, in labs around the world

Video

The PromethION is Oxford Nanopore Technologies' largest sequencing device, capable of delivering many terabases of data, in real time, from a single run. Hear how teams across a broad range of applications, based in labs all over the world — US (UCSF, UCD, JCVI and UCSC), China (GrandOmics and Biomarker) and Europe (KeyGene, Genescope and UMC Utrecht) — are using PromethION in their work.

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Epigenetic Treatments Could Trigger Aggressive Tumors
Epigenetic Treatments Could Trigger Aggressive Tumors
News

A team headed by ICREA researchers Salvador Aznar Benitah and Fran Supek concludes that care should be taken with drugs that inhibit epigenetic factors.

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10-20% of Cells in a Kidney Organoid Found to be Non-Renal
10-20% of Cells in a Kidney Organoid Found to be Non-Renal
News

Single-cell transcriptomics revealed 10-20% of cells in a kidney organoid were non-renal cells.

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Rooting in the Genomes of Giants
Rooting in the Genomes of Giants
News

Giant virus genomes have been discovered for the first time in a forest soil ecosystem.

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Autism Gene Makes Mouse Brains Less Flexible
Autism Gene Makes Mouse Brains Less Flexible
News

About 1% of patients diagnosed with autism spectrum disorder and intellectual disability have a mutation in a gene called SETD5. Scientists have now discovered what happens on a molecular level when the gene is mutated in mice, and how this changes the mice’s behavior.

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Molecule Fights Muscular Paralysis
Molecule Fights Muscular Paralysis
News

UNIGE researchers have identified a molecule that can halt the progress of a severe genetic disease that causes whole-body muscle paralysis followed by death.

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Gene Editing Dramatically Improves Inherited Kidney Disease in Mice
Gene Editing Dramatically Improves Inherited Kidney Disease in Mice
News

Gene editing could be used to stop kidney damage in patients who have Joubert syndrome, an inherited kidney disease.

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Care in the Community – How Biofilms Improve Bacterial Survival
Care in the Community – How Biofilms Improve Bacterial Survival
Article

A single bacterial cell on its own is vulnerable to attack and like many living things they can benefit from safety in numbers. But bacteria take communal living to a whole new level, forming veritable civilizations - the bacterial biofilm.

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Antigenic Drift vs Antigenic Shift
Antigenic Drift vs Antigenic Shift
Article

As part of the host-pathogen arms race, viruses are continually evolving to evade the host immune response, be it from previous infection or immunity acquired through vaccination. Here we take a look at the processes of antigenic drift and antigenic shift.

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Exploiting Epigenetics in Cancer Treatment
Exploiting Epigenetics in Cancer Treatment
Article

Changes to the complex of DNA and the proteins that form chromatin are important drivers in many cancers. We explore the challenges and progress in the development of new therapies targeting epigenetic regulators.

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Exploring the Public’s Perception of Food Fraud
Exploring the Public’s Perception of Food Fraud
Article

When you go to the shops to buy the weekly groceries, it’s quite likely you’ll find yourself thinking about where your food has come from. Is this organic? Is that free-range? You are perhaps less likely to find yourself wondering, “Is this food fake?”

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Understanding the Lytic Cycle – What Are the Steps?
Understanding the Lytic Cycle – What Are the Steps?
Article

Bacteriophage (phage) are viruses that specifically infect bacteria. They have a two-phase lifecycle, residing in a dormant state within the host genome (lysogenic cycle) or hijacking the host cellular machinery for their own replication (lytic cycle). Here we will explore the important steps of the lytic cycle.

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Cold Plasma for Seed, Fruit and Vegetable Decontamination and Plant Disease Control
Cold Plasma for Seed, Fruit and Vegetable Decontamination and Plant Disease Control
Article

An effective way to increase crop yield is to minimize losses to pathogenic microorganisms by improving the disease resistance of crop plants. A recently emerging alternative to conventional methods for improving plant disease resistance is cold plasma.

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