CRISPR-Cas9 ("Mr. Sandman" Parody)

Fun Video

A Capella Science parodies "Mr Sandman" with his latest video (and hopefully teaches you something about CRISPR-Cas9 gene editing).

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10 Things We Didn't Know Last Week - June 22, 2018

List

A roundup of the weeks biggest stories in science

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The Gene Factory: Can Enzymes Revolutionize Man-Made DNA Synthesis?

Article

Building artificial DNA sounds like a technology out of science fiction, but has been conducted in labs for nearly 40 years. To make the potential of synthetic DNA a reality, new methods are being developed that aim to make creating DNA as fast as sequencing it.

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Psychiatric Disorders Share a Common Genetic Basis

Psychiatric Disorders Share a Common Genetic Basis

News

Psychiatric disorders such as schizophrenia and bipolar disorder often run in families. In a new international collaboration, researchers explored the genetic connections between these and other disorders of the brain at a scale that far eclipses previous work on the subject. The team determined that psychiatric disorders share many genetic variants, while neurological disorders (such as Parkinson’s or Alzheimer’s) appear more distinct.

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Mechanism Controlling Multiple Sclerosis Risk Identified
News

Researchers at Karolinska Institutet have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through so-called epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS through the same mechanism.

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Synthetic DNA Shuffling Enzyme Outpaces Natural Counterpart
News

A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. Researchers say their lipid-scrambling DNA enzyme is the first in its class to outperform naturally occurring enzymes – and does so by three orders of magnitude

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Antarctic Worm and Machine Learning Help Identify Cerebral Palsy Earlier
News

A research team has released a study in the peer-reviewed journal BMC Bioinformatics showing that DNA methylation patterns in circulating blood cells can be used to help identify spastic cerebral palsy (CP) patients. The technique which makes use of machine learning, data science and even analysis of Antarctic worms, raises hopes for earlier targeted CP therapies.

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Genetic Analysis Adds Weight to Cannabis Strain Name Concerns
Genetic Analysis Adds Weight to Cannabis Strain Name Concerns
Article

Inconsistent naming and labeling of cannabis strains continue to pose challenges for consumers and researchers alike.

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We're Not Prepared for the Genetic Revolution That's Coming
We're Not Prepared for the Genetic Revolution That's Coming
Article

New technologies are making genetic information (and the power to manipulate it) more widely available that ever before. What the public do with that information, and the effects of those actions, could be a defining theme of the 21st century.

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One Year on, Scientists Defend Canada’s Anti-Genetic Discrimination Law
One Year on, Scientists Defend Canada’s Anti-Genetic Discrimination Law
Article

The Canadian Genetic Non-Discrimination Act (GNA), introduced last May, made it illegal to require individuals to disclose genetic test results or to compel individuals to undergo genetic tests for any agreement or service. However, a subsequent legal challenge has prompted a robust defense of the act from scientists in the May issue of the Canadian Medical Association Journal (CMAJ).

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Metagenomics: Exploring Microbiomes at Nature’s New Frontiers
Metagenomics: Exploring Microbiomes at Nature’s New Frontiers
Article

Advances in sequencing technologies are providing scientists with a powerful way to view microbial communities in unprecedented detail. Metagenomics is a rapidly evolving field that is uncovering a wealth of hidden biodiversity, revolutionizing our understanding of uncharted corners in the living world.

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Tracking the Heritability of Cell Stress
Tracking the Heritability of Cell Stress
Article

As part of work recently published in Science Advances, a team of researchers from the Institute of Systems Biology at Yale University has built a microfluidic device to demonstrate that single cells preserve a memory of their mother's dynamic response to glucose limitation stress for multiple generations.

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The 3D Structure of Telomerase: Uncovering Its Role in Human Disease
The 3D Structure of Telomerase: Uncovering Its Role in Human Disease
Article

Researchers have published the first detailed picture and description of the 3-dimensional molecular structure of telomerase – a discovery that could enable better targeted drug screening and could result in more successful telomerase-related clinical therapeutics.

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