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PromethION in action, in labs around the world

Video

The PromethION is Oxford Nanopore Technologies' largest sequencing device, capable of delivering many terabases of data, in real time, from a single run. Hear how teams across a broad range of applications, based in labs all over the world — US (UCSF, UCD, JCVI and UCSC), China (GrandOmics and Biomarker) and Europe (KeyGene, Genescope and UMC Utrecht) — are using PromethION in their work.

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8 Tips for Improving Your NGS Libraries

List

For most laboratory workflows, you’re only as good as your starting material. This is particularly true for next-generation sequencing (NGS). Library quality is all-important in ensuring you receive high quality data.

Whilst each platform and each type of NGS experiment will require its own optimization, there are several tips and tricks to preparing NGS libraries that hold true across all applications, which we've complied in this handy list.

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$3.6 Million to Study Adverse Effects of Genome Editing

$3.6 Million to Study Adverse Effects of Genome Editing

News

As genome editing technologies advance toward clinical therapies, they are raising hopes of a completely new way to treat disease. However, challenges need to be addressed before potential treatments can be widely used in patients. To tackle these challenges, the National Institutes of Health has launched the Somatic Cell Genome Editing program, which has awarded multiple grants including more than $3.6 million to assess the safety of genome editing in human cells and tissues.

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Sequencing Offers New Hope for Rare Cancers
News

A cancer’s genetic sequence may be the key to matching people with rare cancers to the right anti-cancer treatments, according to a new clinical trial instigated by patients.

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Synthetic Molecule Invades Double-stranded DNA
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Researchers have developed a synthetic molecule that can recognize and bind to double-stranded DNA or RNA under normal physiological conditions. The molecule could provide a new platform for developing methods for the diagnosis and treatment of genetic conditions.

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Saliva-based Biomarkers and Algorithm Could Aid Autism Diagnosis
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A saliva-based biomarker panel and algorithm could help fast-track the identification of children who are suspected of having autism spectrum disorder.

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Care in the Community – How Biofilms Improve Bacterial Survival
Care in the Community – How Biofilms Improve Bacterial Survival
Article

A single bacterial cell on its own is vulnerable to attack and like many living things they can benefit from safety in numbers. But bacteria take communal living to a whole new level, forming veritable civilizations - the bacterial biofilm.

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Antigenic Drift vs Antigenic Shift
Antigenic Drift vs Antigenic Shift
Article

As part of the host-pathogen arms race, viruses are continually evolving to evade the host immune response, be it from previous infection or immunity acquired through vaccination. Here we take a look at the processes of antigenic drift and antigenic shift.

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Exploiting Epigenetics in Cancer Treatment
Exploiting Epigenetics in Cancer Treatment
Article

Changes to the complex of DNA and the proteins that form chromatin are important drivers in many cancers. We explore the challenges and progress in the development of new therapies targeting epigenetic regulators.

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Exploring the Public’s Perception of Food Fraud
Exploring the Public’s Perception of Food Fraud
Article

When you go to the shops to buy the weekly groceries, it’s quite likely you’ll find yourself thinking about where your food has come from. Is this organic? Is that free-range? You are perhaps less likely to find yourself wondering, “Is this food fake?”

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Understanding the Lytic Cycle – What Are the Steps?
Understanding the Lytic Cycle – What Are the Steps?
Article

Bacteriophage (phage) are viruses that specifically infect bacteria. They have a two-phase lifecycle, residing in a dormant state within the host genome (lysogenic cycle) or hijacking the host cellular machinery for their own replication (lytic cycle). Here we will explore the important steps of the lytic cycle.

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Cold Plasma for Seed, Fruit and Vegetable Decontamination and Plant Disease Control
Cold Plasma for Seed, Fruit and Vegetable Decontamination and Plant Disease Control
Article

An effective way to increase crop yield is to minimize losses to pathogenic microorganisms by improving the disease resistance of crop plants. A recently emerging alternative to conventional methods for improving plant disease resistance is cold plasma.

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