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Latest App Notes & Case Studies

App Note / Case Study

The Importance of Reproducibility for Gene Therapy Development

The scale of research into potential gene therapies often means that work is distributed across multiple locations. Investigators must have confidence that the results obtained at one site are consistent with results obtained at other sites participating in the study.
App Note / Case Study

Optimizing the Isolation of Cell-Free DNA From Liquid Biopsy Samples

Diagnostic tests are at the core of medicine. Liquid biopsies in particular are incredibly valuable, giving a more holistic disease profile and making it easier to measure a condition over time.
App Note / Case Study

Tissue Dissociation for Single-Cell Sequencing

With recent technological advancements, single-cell sequencing can now allow tens of thousands of individual cells from a single tissue sample to be analyzed, giving researchers an unprecedented opportunity to understand individual cell populations and their behavior in diseased tissue.
App Note / Case Study

Resolve the Complex Cellular Diversity of Your Samples

Single-cell RNA sequencing produces a substantial amount of complex data that can be a burden if you don’t have time to become an expert in bioinformatics.
App Note / Case Study

The Impact of Genomic DNA Handling Protocols on Sample Quality

Before you can embark on one of the many applications involving genomic DNA (gDNA), it is important to assess the quality of your samples, especially if these samples could have been exposed to physical shearing or enzymatic degradation.
App Note / Case Study

A Novel Method To Assess Sequence Integrity for RNA Therapeutics

RNA-based therapies can modulate cells in a controlled and targeted manner, effectively acting as gene therapies. But, as with any therapeutic, RNA therapeutics must undergo strict quality control (QC) to ensure the product is exactly as specified, with no errors or alternate products.
App Note / Case Study

Advanced Flow Cytometry for Cell Line Development

Traditional methods are often low throughput, time-consuming and lack linearity. However, advanced flow cytometry has emerged as a more efficient alternative for biologics development.
App Note / Case Study

Maximize Your Long-Read Sequencing Results

Routine, robust methods for long-read sequencing have the potential to allow researchers to analyze long stretches of DNA without the requirement of preamplification and can also enable analysis of complex regions that are otherwise difficult to map.
App Note / Case Study

Automated Parallel Capillary Electrophoresis for Purity Analysis of ssDNA and RNA Oligonucleotides

As oligonucleotides (oligos) are synthesized, small amounts of impurities can be introduced at each step, and different synthesis methods and purification efficiencies can impact the quality of the sample.
App Note / Case Study

An Integrated Multiomic Approach for the Diagnosis of Metabolic Diseases

Inherited metabolic disorders (IMDs) are a vast and complex group of rare genetic diseases presenting throughout a patient’s life span.
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