Latest App Notes & Case Studies

The scale of research into potential gene therapies often means that work is distributed across multiple locations. Investigators must have confidence that the results obtained at one site are consistent with results obtained at other sites participating in the study.

Diagnostic tests are at the core of medicine. Liquid biopsies in particular are incredibly valuable, giving a more holistic disease profile and making it easier to measure a condition over time.

With recent technological advancements, single-cell sequencing can now allow tens of thousands of individual cells from a single tissue sample to be analyzed, giving researchers an unprecedented opportunity to understand individual cell populations and their behavior in diseased tissue.

Single-cell RNA sequencing produces a substantial amount of complex data that can be a burden if you don’t have time to become an expert in bioinformatics.

Before you can embark on one of the many applications involving genomic DNA (gDNA), it is important to assess the quality of your samples, especially if these samples could have been exposed to physical shearing or enzymatic degradation.

RNA-based therapies can modulate cells in a controlled and targeted manner, effectively acting as gene therapies. But, as with any therapeutic, RNA therapeutics must undergo strict quality control (QC) to ensure the product is exactly as specified, with no errors or alternate products.

Traditional methods are often low throughput, time-consuming and lack linearity. However, advanced flow cytometry has emerged as a more efficient alternative for biologics development.

Routine, robust methods for long-read sequencing have the potential to allow researchers to analyze long stretches of DNA without the requirement of preamplification and can also enable analysis of complex regions that are otherwise difficult to map.

As oligonucleotides (oligos) are synthesized, small amounts of impurities can be introduced at each step, and different synthesis methods and purification efficiencies can impact the quality of the sample.

Inherited metabolic disorders (IMDs) are a vast and complex group of rare genetic diseases presenting throughout a patient’s life span.