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Application Notes

 
Capture-Based SNP Genotyping with Twist Target Enrichment Panels
Application Note

In the past two decades, genotyping arrays have been instrumental in the large-scale characterization of single nucleotide polymorphisms (SNPs) and the genetic makeup of individuals. Targeted sequencing has yet to fully replace microarrays due to barriers associated with performance at scale.

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Automated Nucleic Acid Extraction and RT-PCR Set-Ups for SARS-CoV-2 Testing
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To prevent new infections in China once the number of cases fell, all nationals returning from other countries were tested. This process required rapid testing and automation of the sample preparation process. In order to meet these requirements, scientists have exploited automated pipetting solutions. Download this app note to discover tips on how to automate the testing of suspected COVID-19 positive cases.

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COVID-19: Automated Solutions To Meet Testing and Sample Handling Requirements
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When COVID-19 arrived very few people had anticipated the impact a pandemic would have on the global population and the life sciences industry. Many laboratories are archiving positive COVID-19 samples for future research. Access this app note to discover the uses and advantages of automated storage.

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How To Beat Bias in Directed Evolution of Biocatalysts
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Because of problems in common PCR-based mutagenesis techniques, there is an urgent need to develop efficient screening and selection tools for biocatalyst improvement. Download this app note to discover a novel approach using solid-phase synthesis of oligonucleotides

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Effectiveness of CRISPR-Cas9 Using Pools of Synthetic cRNAs in Screening Experiments
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Download this app note to discover an example that shows pooling crRNAs to the same gene target provides robust functional knockout and reveal ways to ensure crRNA pools work successfully in phenotypic screening.

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Studying the Molecular Mechanism of Viral Replication in Real Time
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Viruses are obligate intracellular pathogens that can infect all living organisms. A clear understanding of host–virus interactions is crucial to uncover the molecular mechanisms underpinning infection and to enable the development of new treatments.

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Illuminating the Role of the Adaptive Immune Response in Neurodegeneration
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Download this research snapshot to discover how immune repertoire changes in patients with age-related neurodegeneration and how adaptive immune cells are involved in these neurodegenerative diseases.

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Latest Methods on RNA Analysis From Small to Large
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Download this info kit to learn more about how capillary electrophoresis is used in the biopharma industry.

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Combining NGS Technologies for Biomarker Identification and Confirmation Research
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Download this app note to learn more about NGS and the benefits of different approaches used for the diagnosis of diseases including circulating tumors.

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Employing NGS Tumor Profiling To Discover Targetable Cancer Biomarkers
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Download this app note to learn more about data quality and library complexity using next-generation sequencing.

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