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Latest App Notes & Case Studies

An Integrated Multiomic Approach for the Diagnosis of Metabolic Diseases content piece image
App Note / Case Study

An Integrated Multiomic Approach for the Diagnosis of Metabolic Diseases

Inherited metabolic disorders (IMDs) are a vast and complex group of rare genetic diseases presenting throughout a patient’s life span.
Improving qPCR Reliability With Automated RNA Normalization and Plate Setup content piece image
App Note / Case Study

Improving qPCR Reliability With Automated RNA Normalization and Plate Setup

Quantitative real time PCR, often coupled with reverse transcription (RT-qPCR), is a powerful technique for detecting differences in the copy number of nucleic acids and can be used for analysis of gene expression.
Distinguishing Oxidative Impurities From Ionizable Lipids Used in LNP Formulations content piece image
App Note / Case Study

Distinguishing Oxidative Impurities From Ionizable Lipids Used in LNP Formulations

Lipid nanoparticles (LNPs), comprised of ionizable lipids, are used to deliver oligonucleotides to work as therapeutics or to stimulate the immune system, as in the initial mRNA-based COVID vaccines.
CIRCLE-Seq for CRISPR/Cas9 Off-Target Screening content piece image
App Note / Case Study

CIRCLE-Seq for CRISPR/Cas9 Off-Target Screening

CRISPR/Cas9 gene editing can result in off-target cleavage events, impacting the validity of your final results. Cleavage of unintended targets can cause impaired cell function, cell death or misleading conclusions. CIRCLE-seq is a sensitive in vitro assay that was developed to overcome the challenges associated with off-target screening.
Recombinant Protein Expression Using a Baculovirus–Insect Cell System content piece image
App Note / Case Study

Recombinant Protein Expression Using a Baculovirus–Insect Cell System

Download this app note to discover a method of recombinant protein expression that enables correct protein folding and post translational modification, is suitable for high-density cell culture, and can produce both secreted and intracellular proteins of various species.
Comparison of Different Methods To Isolate High Molecular Weight DNA From Bacteria content piece image
App Note / Case Study

Comparison of Different Methods To Isolate High Molecular Weight DNA From Bacteria

Find out how scientists determined which of five extraction methods was optimal for use in a long-read sequencing workflow by comparing the sample quality, sample size and sequencing results.
Ensuring Quality Control of IVT RNA Workflows content piece image
App Note / Case Study

Ensuring Quality Control of IVT RNA Workflows

From vaccines to gene therapies, RNA produced by in vitro transcription (IVT) has many therapeutic applications.
High Resolution Mapping of the Breast Cancer Tumor Microenvironment content piece image
App Note / Case Study

High Resolution Mapping of the Breast Cancer Tumor Microenvironment

Single cell and spatial technologies that profile gene expression across whole tissues are revolutionizing the resolution of molecular states in clinical tissue samples.
The Medical Scientists Pioneering Genomic Data Sharing content piece image
App Note / Case Study

The Medical Scientists Pioneering Genomic Data Sharing

Data silos, lack of interoperability and the preservation of patient privacy all present challenges to the global sharing of genomic data.

DNA Purity Ratio content piece image
App Note / Case Study

DNA Purity Ratio

Many downstream experiments in molecular biology, such as next-generation sequencing, depend on the use of reasonably pure nucleic acid samples in adequate concentration ranges.
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