Latest App Notes & Case Studies

Routine, robust methods for long-read sequencing have the potential to allow researchers to analyze long stretches of DNA without the requirement of preamplification and can also enable analysis of complex regions that are otherwise difficult to map.

As oligonucleotides (oligos) are synthesized, small amounts of impurities can be introduced at each step, and different synthesis methods and purification efficiencies can impact the quality of the sample.

Inherited metabolic disorders (IMDs) are a vast and complex group of rare genetic diseases presenting throughout a patient’s life span.

Quantitative real time PCR, often coupled with reverse transcription (RT-qPCR), is a powerful technique for detecting differences in the copy number of nucleic acids and can be used for analysis of gene expression.

Lipid nanoparticles (LNPs), comprised of ionizable lipids, are used to deliver oligonucleotides to work as therapeutics or to stimulate the immune system, as in the initial mRNA-based COVID vaccines.

CRISPR/Cas9 gene editing can result in off-target cleavage events, impacting the validity of your final results. Cleavage of unintended targets can cause impaired cell function, cell death or misleading conclusions. CIRCLE-seq is a sensitive in vitro assay that was developed to overcome the challenges associated with off-target screening.

Download this app note to discover a method of recombinant protein expression that enables correct protein folding and post translational modification, is suitable for high-density cell culture, and can produce both secreted and intracellular proteins of various species.

Find out how scientists determined which of five extraction methods was optimal for use in a long-read sequencing workflow by comparing the sample quality, sample size and sequencing results.

This tech note highlights technology that switches easily between DNA and RNA analysis to ensure quick and reliable quality checks and precise sizing of DNA and IVT RNA products.

Single cell and spatial technologies that profile gene expression across whole tissues are revolutionizing the resolution of molecular states in clinical tissue samples.