Latest App Notes & Case Studies

App Note / Case Study
Achieve Highly Sensitive Viral Detection with the SARS-CoV-2 NGS Assay - RUO
Download this application focus to learn more about the solutions available to optimize the sensitivity of viral detection.

App Note / Case Study
Genomic DNA Extractions Compared With the Agilent Femto Pulse System
Large-insert libraries require specific quality conditions of the starting genomic DNA (gDNA) material for successful outcomes. Physical, enzymatic and chemical shearing of gDNA into smaller fragments can occur at many different points during extraction and handling of gDNA.

App Note / Case Study
High-Performance Exome Enrichment With Integrated Analysis Software
While identifying single nucleotide variants (SNVs) and small insertions/deletions (indels) from NGS data has become routine and well established, it is still quite a challenge to accurately detect germline copy-number variations (CNVs) from exome sequencing data as compared to the more conventional methodologies for CNV detection, including comparative genome hybridization arrays.

App Note / Case Study
Improved GPCR Engineering With Synthetic Site Saturation Variant Libraries
Download this app note to learn more about how saturation mutagenesis can be used to identify functional GPCR variants, why error-prone PCR results in low variant representation as well as the advantages of synthetic saturation mutagenesis libraries.

App Note / Case Study
SARS-CoV-2 Spike Protein Mutagenesis
Variants of SARS-CoV-2 have been emerging and circulating around the world since the start of the COVID-19 pandemic. Recombinant proteins, particularly those corresponding to variants of spike (S) protein, are required to study transmissibility and immune escape.

App Note / Case Study
Resolving Brain Architecture With Comprehensive Spatial Gene Expression
Spatially resolved gene expression can provide a powerful complement to traditional histopathology methods, enabling a greater understanding of cellular heterogeneity and organization within the central nervous system.

App Note / Case Study
Genome Integrity Analysis of Adeno-Associated Viruses (AAV) Using Multi-Capillary Gel Electrophoresis
An AAV is a non-enveloped virus with a lack of pathogenicity, low immunogenicity, broad tropism and persistent transgene expression in both proliferating and quiescent cells. This makes AAVs an attractive choice for creating viral vectors for gene therapy for a variety of diseases.

App Note / Case Study
Pushing the Boundaries of High Sensitivity Epigenetic Applications
Download this free application focus to learn more about innovative next-generation methylation detection systems.

App Note / Case Study
Targeted Methylation Sequencing
Download this app note to discover methylation capture panels that show excellent performance across a wide range of methylation targets, enable highly optimized designs out of the box and are compatible with enzymatic or bisulfite conversion.

App Note / Case Study
Microbubbles Offer a Versatile, Flexible Platform for Targeted Capture of Diverse Analytes
Download this app note to discover a solution that can be used with any biotinylated affinity molecule, enables floatation-based separation of diverse targets as well as provides workflows that are exceptionally gentle on delicate analytes.
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