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Application Notes

 
Next Generation Sequencing Method for Illumina TruSeq DNA Sample Preparation Protocol on the Hamilton STAR
Application Note

Hamilton

The purpose of the TruSeq sample preparation protocol is to add adapter sequences onto the ends of DNA fragments to generate multiplexed sequencing libraries. Good liquid handling is crucial for pipetting precise volumes for example for Agilent Bioanalyzer.

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Automated GS FLX Titanium emPCR Enrichment using the REM e System on a Hamilton Microlab® STARlet Liquid Handler
Application Note

Hamilton

The Genome Sequencer FLX System is a versatile sequencing platform suitable for a wide range of research applications, including de novo sequencing and assembly of genomic DNA, transcriptome sequencing, small RNA analysis, and amplicon sequencing.

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A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1)
Application Note

BMG Labtech

Post-translational histone modifications like acetylation play a pivotal role in the epigenetic regulation of transcription. Catalyzing the latter reaction HDACs affect various cellular processes especially cancerogenesis. Although the mechanism of starting cancerogenesis by epigenetic events is not clearly explained inhibition of HDACs has highlighted as a viable principle in cancer therapy.

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Analysis of Organophosphorus Pesticides with Agilent 7820 Gas Chromatograph Flame Photometric Detector
Application Note

The Agilent 7820 series gas chromatograph (GC) equipped with a flame photometric detector (FPD) provides high sensitivity, good linearity, and stability for the analysis of organophosphorus pesticides.

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Automation of a Generic Fluorescent Methyltransferase Activity Assay
Application Note

BioTek Instruments Inc.

The primary function of this application note is to demonstrate automated methods for a HTS-ready universal methyltransferase activity assay.

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A MIQE Case Study — Effect of RNA Sample Quality and Reference Gene Stability on Gene Expression Data
Application Note

Bio-Rad Laboratories

In this study, the minichromosome maintenance (MCM) protein, MCM7, was selected as a model target gene to investigate the importance of appropriate reference gene selection and RNA sample quality as described by the MIQE guidelines.

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Tools for Enhancing Sequence Diversity and Reducing Bias in DNA-seq Library Preparation
Application Note

Bioo Scientific

The generation of high quality next generation sequencing data begins with libraries that have the desired insert size and proper adapter ligation.

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Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Application Note

Molecular Devices

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.

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Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Application Note

Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.

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DNA Measurements in Low Volume Samples, Microplates and Cuvettes on the SPECTROstar Nano
Application Note

BMG Labtech

This application note details how the SPECTROstar Nano absorbance reader measures nucleotides such as DNA in microplates, cuvettes and low volume samples with the BMG LABTECH’s LVis Plate.

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