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Identifying Genetic Drivers of Innate Immunity Using Custom Targeted CRISPR Screens

CRISPR knock-out screens provide a powerful tool for the investigation of highly coordinated cellular processes. Using genome-wide CRISPR knockout screens, followed by focused CRISPR screens, researchers at Boehringer Ingelheim probed the gene-phenotype relationship of human monocyte phagocytosis when the cells were challenged with Staphylococcus aureus.

Download this app note to discover how researchers were able to: 

  • Produce high-quality, customized oligos for CRISPR screens
  • Identify a number of genes that affect phagocytosis in human monocytes
  • Avoid the cost and time impact associated with validating hits generated by genome-wide screens