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Identifying Genetic Drivers of Innate Immunity Using Custom Targeted CRISPR Screens
Application Note

Identifying Genetic Drivers of Innate Immunity Using Custom Targeted CRISPR Screens

Identifying Genetic Drivers of Innate Immunity Using Custom Targeted CRISPR Screens
Application Note

Identifying Genetic Drivers of Innate Immunity Using Custom Targeted CRISPR Screens

CRISPR knock-out screens provide a powerful tool for the investigation of highly coordinated cellular processes. Using genome-wide CRISPR knockout screens, followed by focused CRISPR screens, researchers at Boehringer Ingelheim probed the gene-phenotype relationship of human monocyte phagocytosis when the cells were challenged with Staphylococcus aureus.

Download this app note to discover how researchers were able to: 

  • Produce high-quality, customized oligos for CRISPR screens
  • Identify a number of genes that affect phagocytosis in human monocytes
  • Avoid the cost and time impact associated with validating hits generated by genome-wide screens
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