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Large DNA Fragment Analysis: Constant- vs Pulsed-Field Electrophoresis Technologies

Credit : Istock

Measuring the size and integrity of fragment DNA is an essential quality control step in next-generation sequencing (NGS) workflows. Hence, it is critical to choose the most appropriate electrophoresis technology to obtain accurate and reliable results. 

Selecting the appropriate technology for analyzing HMW samples and large DNA smears is important to avoid problems such as DNA stacking or poor sizing.

This application note compares the use of pulsed- and constant-field technologies to support researchers in choosing the most suitable  automated instrument for their sequencing workflow.

Download this application note to learn more about:

  • Choosing the most suitable automated electrophoresis system for your needs
  • Resolution differences between constant- and pulsed-field separation
  • Quality control of HMW or sheared genomic DNA in NGS library preparation

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