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Microflow Chromatography: A Key to More Sensitive Metabolite Identification

In early-stage pharmaceutical research, knowledge of a compound’s metabolism can assist in the identification of structural liabilities that can contribute to non-optimal pharmacokinetics, potentially toxic breakdown products or the potential for drug-drug interactions.

Download this app note to discover how switching from a traditional high flow chromatographic separation to microflow chromatography for metabolite analysis can: 

  • Improve the sensitivity for the analysis of microsomal incubation samples
  • Lead to the identification of more metabolites with a higher degree of confidence
  • Provide more complete metabolic profiling from the same amount of sample