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Tiling Across Viral Genomes to Investigate Immune Escape

Viruses exploit high-dimensional RNA structures to facilitate viral replication and impede host restriction. Here, a novel next-generation sequencing (NGS)-based screening workflow, called Fate-seq, was used to define and characterize high-dimensional RNA structures from the severe acute respiratory syndrome coronavirus (SARS-CoV) genome in an unbiased, high-throughput, and comprehensive manner.

Download this app note to learn about:

  • Details on Fate-seq, a new method for high-throughput analysis of RNA secondary
  • How 300mer oligos can be used to tile across a genome to interrogate its function
  • How RNA secondary structures in SARS-CoV and SARS-CoV-2 may contribute to immune escape