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truCOLLECT® Solution: High-Fidelity Genomic DNA Extraction from Decentralized, Dry-Stabilized Whole Blood for Biomarker Identification

Covaris technical note on truCOLLECT solution for high-fidelity genomic DNA extraction from dry-stabilized whole blood samples
Credit: Covaris.

Engineered specifically to address the operational gaps typically faced in decentralized testing, the Covaris truCOLLECT
Whole Blood Collection Kit, combined with AFA extraction technology, presents a robust and reliable integrated solution. As demonstrated by the extensive performance evaluation conducted by Ambry Genetics, the truCOLLECT Solution enables the reliable self-collection of 50 μL of capillary blood, which is immediately stabilized in a proprietary active-desiccation format and rapidly processed upon arrival using the Covaris R230 Focused-ultrasonicator. By combining this patient-centric sampling with automated precision, the truCOLLECT Solution yields superior HMW gDNA that provides genomic fidelity comparable to traditional phlebotomy. Characterized by seamless NGS pipeline integration, including 100% library preparation success, 99.9% clinical variant concordance, and confirmed compatibility across Sanger, MLPA, and array platforms, the system effectively 
mitigates current operational inefficiencies. By eliminating cold-chain logistics, the truCOLLECT Solution enables laboratories to scale population genomics, and precision oncology initiatives efficiently and cost-effectively.