In this article, we will explore the manufacturing strategies and tools that the biopharmaceutical industry adopted to make such efficient COVID-19 vaccine production possible.READ MORE
In normal health, Ras signaling is central to the regulation of intracellular signaling networks involved in cell proliferation, growth and survival. Like many cellular signaling pathways, however, the Ras-related cascade has a dark side. Mutations in the RAS gene itself, or in upstream or downstream regulators, can push the pathway into a constitutively active, cancer-inducing state.
Fred “Rusty” Gage is president of the Salk Institute for Biological Studies. After his recent plenary at the British Neuroscience Association’s Festival of Neuroscience, we spoke with Gage about his research into how our DNA repairs itself and how Alzheimer's disease causes neurons to undergo and identity crisis.READ MORE
CAR T cells are living cells, which means manufacturers, in part, depend on the cells' physiological workings to integrate and express the CAR gene in the appropriate quantity. Since this process is not entirely under a manufacturer’s control, the process of generating safe and effective CAR T cells requires meticulous quality control.READ MORE
In a new study published in Cell Metabolism, scientists share their discovery of a novel, non-invasive biomarker test that can be utilized to measure and track the performance of senolytic drugs.READ MORE
In the UK, Genomics England is pioneering a "lasting legacy" for patients by introducing genomic sequencing into the wider healthcare system. Technology Networks interviewed Clinical Director Dr Richard Scott, to find out more.READ MORE
Ribonucleic Acid (RNA) polymerase is an intermediary enzyme responsible for processing gene sequences into RNA-based genetic material that can be utilized in protein synthesis. In this article, we define RNA polymerase and further explore its various functions throughout cell biology.
The incredible efforts of scientists and public health agencies worldwide in response to SARS-CoV-2 has resulted in the emergency use authorization and rapid deployment of antibody-based countermeasures, including therapies and vaccines. Their effectiveness is typically measured in a neutralization assay, however, biosafety restrictions make working with SARS-CoV-2 challenging. We take a look at how pseudovirus may offer an alternative tool.READ MORE