Latest Articles

In normal health, Ras signaling is central to the regulation of intracellular signaling networks involved in cell proliferation, growth and survival. Like many cellular signaling pathways, however, the Ras-related cascade has a dark side. Mutations in the RAS gene itself, or in upstream or downstream regulators, can push the pathway into a constitutively active, cancer-inducing state.

Fred “Rusty” Gage is president of the Salk Institute for Biological Studies. After his recent plenary at the British Neuroscience Association’s Festival of Neuroscience, we spoke with Gage about his research into how our DNA repairs itself and how Alzheimer's disease causes neurons to undergo and identity crisis.

In a new study published in Cell Metabolism, scientists share their discovery of a novel, non-invasive biomarker test that can be utilized to measure and track the performance of senolytic drugs.

In the UK, Genomics England is pioneering a "lasting legacy" for patients by introducing genomic sequencing into the wider healthcare system. Technology Networks interviewed Clinical Director Dr Richard Scott, to find out more.

Ribonucleic Acid (RNA) polymerase is an intermediary enzyme responsible for processing gene sequences into RNA-based genetic material that can be utilized in protein synthesis. In this article, we define RNA polymerase and further explore its various functions throughout cell biology.

The EMBL-EBI announced that it had launched the Genome Integrations with Function and Sequence, or GIFTS, platform in January. This will enable scientists that are using Ensembl and UniProt to access all of the up-to-date genomic and protein data for human and mouse genomes. Technology Networks spoke with the scientists behind GIFTS to learn more.

In this article, we explore the tumor microenvironment (TME), immune infiltration, particularly macrophages, as well as epigenetically-regulated metabolic rewiring.

Over the last 56 years, researchers have been developing methods and technologies to assist in the determination of nucleic acid sequences in biological samples. Our ability to sequence DNA and RNA accurately has had a great impact in numerous research fields. This article discusses what next-generation sequencing (NGS) is, advances in the technology and its applications.

Polymerase chain reaction (PCR) is a technique that has revolutionized the world of molecular biology and beyond. In this article, we will discuss a brief history of PCR and its principles, highlighting the different types of PCR and the specific purposes to which they are being applied.

Antimicrobial resistance (AMR) is the ability of microorganisms to resist the killing capacity of antimicrobial drugs, a worryingly increasing problem. This article explores the science behind AMR, factors promoting its spread and techniques to detect it. Looking to the future, ways to combat AMR and alternatives to antimicrobials are discussed.