Non-Invasive Biomarker Can Track and Verify Senolytic Drug Efficacy
In a new study published in Cell Metabolism, scientists share their discovery of a novel, non-invasive biomarker test that can be utilized to measure and track the performance of senolytic drugs.
Genome Sequencing in Modern Medicine: An Interview With Genomics England
In the UK, Genomics England is pioneering a "lasting legacy" for patients by introducing genomic sequencing into the wider healthcare system. Technology Networks interviewed Clinical Director Dr Richard Scott, to find out more.
RNA Polymerase: Function and Definition
Ribonucleic Acid (RNA) polymerase is an intermediary enzyme responsible for processing gene sequences into RNA-based genetic material that can be utilized in protein synthesis. In this article, we define RNA polymerase and further explore its various functions throughout cell biology.
New Platform Connects the Genome and Proteome Worlds
The EMBL-EBI announced that it had launched the Genome Integrations with Function and Sequence, or GIFTS, platform in January. This will enable scientists that are using Ensembl and UniProt to access all of the up-to-date genomic and protein data for human and mouse genomes. Technology Networks spoke with the scientists behind GIFTS to learn more.
The Tumor Microenvironment: Local Effects With Widespread Consequences
In this article, we explore the tumor microenvironment (TME), immune infiltration, particularly macrophages, as well as epigenetically-regulated metabolic rewiring.
An Overview of Next-Generation Sequencing
Over the last 56 years, researchers have been developing methods and technologies to assist in the determination of nucleic acid sequences in biological samples. Our ability to sequence DNA and RNA accurately has had a great impact in numerous research fields. This article discusses what next-generation sequencing (NGS) is, advances in the technology and its applications.
An Introduction to PCR
Polymerase chain reaction (PCR) is a technique that has revolutionized the world of molecular biology and beyond. In this article, we will discuss a brief history of PCR and its principles, highlighting the different types of PCR and the specific purposes to which they are being applied.
Antimicrobial resistance (AMR) is the ability of microorganisms to resist the killing capacity of antimicrobial drugs, a worryingly increasing problem. This article explores the science behind AMR, factors promoting its spread and techniques to detect it. Looking to the future, ways to combat AMR and alternatives to antimicrobials are discussed.
Talking COVID-19 and Genetic Variants With Dr Jeffrey Barrett
The Wellcome Sanger Institute is sequencing the genomes of tens of thousands of COVID-19 samples. In this interview, we're joined by Dr Jeffrey Barrett, director and lead COVID-19 statistical geneticist of the COVID-19 Genomics Initiative at the institute. He explains the importance of applying genomics tools to study pathogens, discusses the initiative's role in exploring variants of concern and outlines how the generated data is being applied to inform public health decisions.
Why Are Some Coronavirus Strains More Infectious Than Others?
What makes one coronavirus more infectious than the other? The lab of or Dr Mahmoud Moradi at the University of Arkansas has used molecular simulations, performed at the Texas Advanced Computing Center and the Pittsburgh Supercomputing Center, to investigate this question.