A Genome-wide Look at Post-Transcriptional Gene Regulation
Conference Recording Jun 15, 2013
About the Speaker
Jason was mentored by Jim Ferrell at Stanford University. During this time, he developed, patented, licensed and facilitated commercialization of the In Vitro Dicing Technology. In a collaborative effort with Tobias Meyer, Jason developed high-throughput and high-content screening methods to understand cellular signaling processes. Recombinant Dicing Kits have been used extensively by researchers to elucidate gene function. As a postdoctoral fellow in Pat Brown's lab Jason developed microarray-based methods to investigate genome-wide post-transcriptional gene expression. These methods have been used to understand the regulation of gene expression in yeast and humans, including how miRNAs regulate the translation of mRNAs. Jason was one of the first employees at Ion Torrent and helped to develop the biochemical aspects of the Ion Torrent Technology. Currently he leads an R&D group responsible for developing sequencing-based applications for the Ion Torrent PGM.AbstractThe combination of RNA Seq and RNA biochemistry is enabling a deeper understanding of the post-transcriptional regulation of gene expression. Until recently the efficiency of next-generation sequencing has limited the number and depth of RNA Seq studies. Ion Torrent Semiconductor Sequencing™ delivers RNA sequencing at an unprecedented speed, scalability and cost enabling in depth analysis of post-transcriptional gene regulation.