Long Non-coding RNA in Cancer
Conference Recording Jan 05, 2014
About the Speaker
Since 2008: Group Leader „Molecular RNA Biology & Cancer“, German Cancer Research Center DKFZ & Institute of Pathology, University of Heidelberg, Germany
2005-2008: Postdoctoral Fellow Harvard Medical School / Massachusetts General Hospital Cancer Center, Boston
Abstract Non-coding RNA profiles in cancer are largely unknown which greatly impedes the discovery of functionally important ncRNAs in tumorigenesis as well as the generation of genome-wide libraries. Here, we define the ncRNA expression landscape of lung, breast and liver cancer as well as normal tissue from the respective organs (N=150). In summary, we provide the first global comprehensive expression map of 17000 long ncRNA expression in a broad range of human tumor and normal tissue samples and discovered many new lncRNAs associated with cancer as well as tissue-, histology- and prognosis-specific ncRNA signatures.