Mobile Silencing RNAs
Conference Recording Dec 04, 2013
About the SpeakerDr Attila Molnar is a Senior Research Associate in Professor David Baulcombe’s lab at the University of Cambridge. He studies the function and regulation of RNA silencing in a variety of model organisms including a single celled alga Chlamydomonas reinhardtii and a flowering plant Arabidopsis thaliana.AbstractRNA silencing is a nucleotide sequence-specific gene regulatory mechanism involved in development, stress responses and pathogenic defence. In flowering plants, RNA silencing is a non-cell-autonomous process. Spreading of RNA silencing across the plant has been recognized for nearly two decades, however, only recent reports from the Voinnet and Baulcombe labs have demonstrated beyond doubt that small non-coding RNAs [21-24 nucleotide (nt), sRNAs] are components of the mobile RNA silencing signal. The different size classes of sRNAs have distinct roles in RNA silencing. The 21nt sRNAs primarily mediate post-transcriptional silencing (PTGS) that involves mRNA cleavage/destabilization or translational inhibition in the cytoplasm. The 24 nt sRNAs are associated with nuclear events including RNA-dependent DNA methylation (RdDM) and histone modifications that can lead to transcriptional gene silencing (TGS). I will discuss the consequences of mobile sRNAs on target gene expression and its potential applications.