Nanoparticle-mediated siRNA Gene Silencing against Brain Disorders
Conference Recording Jun 10, 2014
About the Speaker
Mariarosa Mazza obtained her PhD from the UCL School of Pharmacy working on the formulation of peptide nanofibres for drug delivery. She is a registered pharmacist with the General Pharmaceutical Council and an Associate Member of the Royal Society of Chemistry. She joined the Nanomedicine Lab in 2012 to work on the development of new nanomedicines based on soft and hard materials. In 2013 she was appointed Research Fellow in Nanomedicine at the University of Manchester. Her research focuses on the development of nanofiber-mediated delivery systems, therapeutic models and live imaging technologies.Abstract
Peptide nanofibres (PNFs) find many applications as biomaterials for tissue engineering and have also been studied for neuronal regeneration and brain delivery. Positively charged amphiphilic peptides able to self-assemble into PNFs have been engineered. These fiber-shaped nanoscale constructs can be exploited for the development of effective siRNA therapeutics. In this talk, we will illustrate recent experimental evidence on how peptide nanofibres (PNFs) can be designed as tools for siRNA-mediated gene silencing of specific and surgically-targeted brain foci. PNFs constitute promising nanoscale tools for intervention strategies in various neurological disorders.