UNA (Unlocked Nucleic Acid) as a Key Modification for RNAi Applications
Conference Recording Jan 27, 2013
About the Speaker
Jesper Wengel is professor of bioorganic chemistry at the University of Southern Denmark and Director of the Nucleic Acid Center, a research center of excellence focused on nucleic acid chemical biology. He is the co-inventor of LNA (locked nucleic acid) and UNA (unlocked nucleic acid) and he is co-founder of RiboTask, a biotech company focused on developing and marketing novel RNA technologies for gene silencing. He has published more than 330 research papers in international journals.AbstractUNA (unlocked nucleic acid) and LNA (locked nucleic acid) are two RNA analogs which display very different RNA-binding properties. It will be reviewed how UNA and LNA modifications can be used to target RNA segments with one focus being on how strategic incorporations of UNA monomers in siRNA constructs enable a combination of potent gene silencing and reduced off-target effects.