The Need for Speed
Infographic Dec 14, 2016
Accelerating the drug discovery process is a key priority for pharmaceutical businesses around the world and the initial screening of large compound libraries continues to be a critical first step. New technologies that offer a competitive edge are greatly sought after – whether that comes in the form of more information, faster screening or deeper understanding.
Mass spectrometry has significant potential to add value to drug discovery research, and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) has emerged as a powerful technique that ticks all the boxes for a new high-throughput screening methodology to increase productivity while reducing costs and waste within the pharmaceutical setting.
The MALDI PharmaPulse (Bruker Daltonics) can achieve speeds of less than 1 second per sample, which equates to an ability to analyze more than 121,000 samples per day. MALDI-TOF is considerably faster than early MS techniques, such as multiplexed liquid chromatography (LC)-MS technology and Solid Phase Extraction (SPE) methods, which have cycle times of up to 30 seconds and around 10 seconds per sample respectively and are considered too slow for routine HTS.
The dawn of forensic DNA analysis has had a large part to play in the evolution of criminal and private investigations. Even the smallest residues can be used to place someone at a crime scene or determine how people are related to one another. Forensic DNA analysis doesn’t stop with people either, law enforcers are using the techniques to combat smuggling of animals and exotic woods too.READ MORE
Like what you just read? You can find similar content on the communities below.Analysis & Separations Applied Sciences Biopharma Cancer Research Cell Science Diagnostics Drug Discovery Informatics Proteomics & Metabolomics Neuroscience Immunology & Microbiology
To personalize the content you see on Technology Networks homepage, Log In or Subscribe for FreeLOGIN SUBSCRIBE FOR FREE