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Retracing the Lineage of Cancer Cells
News Mar 05, 2021Researchers have reconstructed the lineage history of cancer cells in two individuals with a rare blood cancer by calculating when the genetic mutation that gave rise to the disease first appeared. The findings present insights that could inform new approaches for early detection, prevention, or intervention.
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Mutant Protein Clusters Drive Cancer-Causing Aggregates
News Mar 05, 2021A mutation that replaces a single amino acid in a potent tumor-suppressing protein turns it from saint to sinister. A new study demonstrates why this alteration is more damaging than previously thought.
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Development of Antibiotic Resistance Predicted by New Model
News Mar 05, 2021A new study has shown that using theoretical models of bacterial metabolism and reproduction allows scientists to predict the type of resistance that bacteria will develop when they are exposed to antibiotics.
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SARS-CoV-2 Hides From Killer T Cells by Mutating
News Mar 05, 2021Scientists have shown that SARS-CoV-2 can make itself unrecognizable to the T-killer cells of the immune response through mutations. The findings of the research provide important information for the further development of vaccines.
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DNA Fragments Trigger Inflammation in Sickle Cell Disease
News Mar 05, 2021Mitochondrial DNA acts as a danger signal in the body and triggers inflammation in people with sickle cell disease, according to a new study. A better understanding of mitochondrial DNA may provide vital insight into how to stop the underlying chronic inflammation that marks this inherited red blood cell disorder.
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Ancient DNA Provides Insights on How Tuberculosis Shaped the Human Immune System
News Mar 04, 2021COVID-19 is only the latest infectious disease to have had an outsized impact on human life. A new study employing ancient human DNA reveals how tuberculosis has affected European populations over the past 2,000 years, specifically the impact that disease has had on the human genome.
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Accurately Assessing the Transmissibility of New Virus Mutants
News Mar 04, 2021An international team including researchers from Bern has now been able to demonstrate in both the laboratory and in animal models why the D614G variant was able to gain the upper hand over the original SARS-CoV-2 virus.
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Cell Type Implicated in Chronic Pain Identified
News Mar 04, 2021The discovery offers pain researchers a new, precise target to treat inflammation associated with neuropathic pain.
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Step Closer to Eco-Friendly Fungicides Thanks to Protein Discovery
News Mar 04, 2021New research reveals an essential step in scientists' quest to create targeted, more eco-friendly fungicides that protect food crops. Scientists found that plants use extracellular vesicles to launch RNA molecules at fungal invaders, suppressing the genes that make the fungi dangerous.
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Induced Pluripotent Stem Cells Reveal Causes of Disease
News Mar 04, 2021Scientists from the German Cancer Research Center and the European Molecular Biology Laboratory have studied genotype-phenotype relationships in iPSCs using data from approximately one thousand donors.
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