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Ancient Syphilis Genomes Decoded for First Time
Ancient Syphilis Genomes Decoded for First Time
News   Jun 22, 2018

Researchers recovered three genomes of the bacterium Treponema pallidum from skeletal remains from colonial-era Mexico, and were able to distinguish the subspecies that causes syphilis from the subspecies that causes yaws. It was not previously thought possible to recover DNA from this bacterium from ancient samples.

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Antarctic Worm and Machine Learning Help Identify Cerebral Palsy Earlier
Antarctic Worm and Machine Learning Help Identify Cerebral Palsy Earlier
News   Jun 22, 2018

A research team has released a study in the peer-reviewed journal BMC Bioinformatics showing that DNA methylation patterns in circulating blood cells can be used to help identify spastic cerebral palsy (CP) patients. The technique which makes use of machine learning, data science and even analysis of Antarctic worms, raises hopes for earlier targeted CP therapies.

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Synthetic DNA Shuffling Enzyme Outpaces Natural Counterpart
Synthetic DNA Shuffling Enzyme Outpaces Natural Counterpart
News   Jun 22, 2018

A new synthetic enzyme, crafted from DNA rather than protein, flips lipid molecules within the cell membrane, triggering a signal pathway that could be harnessed to induce cell death in cancer cells. Researchers say their lipid-scrambling DNA enzyme is the first in its class to outperform naturally occurring enzymes – and does so by three orders of magnitude

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Mechanism Controlling Multiple Sclerosis Risk Identified
Mechanism Controlling Multiple Sclerosis Risk Identified
News   Jun 22, 2018

Researchers at Karolinska Institutet have now discovered a new mechanism of a major risk gene for multiple sclerosis (MS) that triggers disease through so-called epigenetic regulation. They also found a protective genetic variant that reduces the risk for MS through the same mechanism.

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Herpesvirus and Alzheimer's Link: High abundance of Herpes genes in postmortem Alzheimer's brain tissue
Herpesvirus and Alzheimer's Link: High abundance of Herpes genes in postmortem Alzheimer's brain tissue
News   Jun 21, 2018

Data from three different brain banks to suggest that human herpesviruses are more abundant in the brains of Alzheimer's patients and may play a role in regulatory genetic networks that are believed to lead to the disease.

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Targeting Epigenetic Proteins to Prevent Breast Cancer
Targeting Epigenetic Proteins to Prevent Breast Cancer
News   Jun 20, 2018

Researchers have discovered that epigenetic proteins promote the proliferation of mammary gland stem cells in response to the sex hormone progesterone. The study suggests that inhibiting these proteins with drugs could prevent the development of breast cancer in women at high risk of the disease.

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Penn Medicine Biochemist Receives Major Award for Research on Epigenetic Protein Modifications via Mass Spec
Penn Medicine Biochemist Receives Major Award for Research on Epigenetic Protein Modifications via Mass Spec
News   Jun 20, 2018

Benjamin A.Garcia, PhD, an expert in quantitative proteomics and Presidential Professor of Biochemistry and Biophysics in the Perelman School of Medicine at the University of Pennsylvania, has been awarded the Biemann Medal by the American Society for Mass Spectrometry (ASMS). The early-career award recognizes significant achievement in basic or applied mass spectrometry.

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Gene Editing Technology May Improve Accuracy of Predicting Heart Disease Risk
Gene Editing Technology May Improve Accuracy of Predicting Heart Disease Risk
News   Jun 19, 2018

Scientists may now be able to predict whether carrying a specific genetic variant increases a person’s risk for disease using gene editing and stem cell technologies.

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New Subtype of Prostate Cancer
New Subtype of Prostate Cancer
News   Jun 18, 2018

Researchers led by the University of Michigan Rogel Cancer Center have identified a new subtype of prostate cancer that occurs in about 7 percent of patients with advanced disease.

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Network Biology Reveals Plant Pathogen Targets
Network Biology Reveals Plant Pathogen Targets
News   Jun 18, 2018

How are proteins in the cells of a flowering plant similar to social networks on Twitter or Facebook? And how might both of those be related to the way pathogens make plants or people sick?

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