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How Does Gene Expression Change in Alzheimer's Disease?
An international group of researchers led by the UAB analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer's patients and in people without diagnosed dementia.
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Spatial Mapping of Single-Cell Data Within Tissues
A newly developed computational approach successfully combines data from parallel gene-expression profiling methods to create spatial maps of a given tissue at single-cell resolution.
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A Shortcut for Identifying Genes Associated With Opioid Use Disorder
Researchers developed a shortcut for identifying genes that are associated with opioid use disorder and may contribute to it using only a small number of patient samples.
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Novel Method Converts Human Pluripotent Stem Cells to 8-Cell Embryo-Like Stage
Researchers have developed a rapid and controllable method to convert pluripotent stem cells into totipotent embryo-like cells, which could be used in future for regenerative medicine.
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Clear Picture of How “First Responder” Is Recruited to Sites of DNA Damage
Structural biologists have created a clear picture of how a "911 DNA damage first responder" is recruited to sites of DNA damage.
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Map of Our Senses May Identify Origins of Chronic Pain
Analysis of the transcriptome of dorsal root ganglion cells has identified differences between mouse and human cells that could help seek drug targets for chronic pain.
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Antibiotics Less Effective When Multiple Microbes Are Present
A study has found that much higher doses of antibiotics are needed to eliminate a bacterial infection of the airways when other microbes are present.
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All of Us Research Program Releases Dataset of Almost 100,000 Genome Sequences
Nearly 100,000 highly diverse whole genome sequences are now available through the National Institutes of Health's All of Us Research Program.
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Cellular Atlas of White Fat Tissue Created
Scientists have generated an atlas of the cell types present in the white adipose tissue of humans and mice, allowing them to look at the composition of fat in unprecedented detail.
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Bone Marrow Cancer Discovery Could Help To Identify Drug Targets
Researchers have discovered that patients with an uncommon type of bone marrow cancer called ASXL1-mutant chronic myelomonocytic leukemia have distinctive epigenetic changes that can activate specific genes and cause the cancer to grow more rapidly.
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