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Protein Increases Dementia Risk, Even Without Mutations content piece image
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Protein Increases Dementia Risk, Even Without Mutations

Researchers have identified Apolipoprotein E as a key misfolded protein while exploring dementia-related proteins in the brain.
Promising Target Identified To Break Malaria's Chain of Infecion content piece image
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Promising Target Identified To Break Malaria's Chain of Infecion

Using CRISPR-Cas9 gene-editing technology, researchers have deleted a key gene encoding a protein found in Anopheles gambiae mosquitoes which could prevent the transmission of malaria from mosquitoes to humans.
How Cells “License” the Replication of Their Genome During Cell Division content piece image
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How Cells “License” the Replication of Their Genome During Cell Division

The process of gene "licensing" during replication has been revealed in detail.
Plant Defense "Shields" Overcome When Viral Proteins Join Forces content piece image
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Plant Defense "Shields" Overcome When Viral Proteins Join Forces

New research into how viral proteins interact and can be disabled holds promise to help plants defend themselves against viruses—and ultimately prevent crop losses.

Randomized Trial Explores Impact of Eating Late on Blood Sugar Control content piece image
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Randomized Trial Explores Impact of Eating Late on Blood Sugar Control

Blood sugar control, which is impaired in individuals with diabetes, is affected by various factors—including the timing of meals relative to sleep as well as levels of melatonin, a hormone primarily released at night that helps control sleep-wake cycles.
Gene Variant May Cause Stronger Response to Brain Stimulation content piece image
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Gene Variant May Cause Stronger Response to Brain Stimulation

The gene of the brain-derived neurotrophic factor (BDNF) is associated with memory and brain plasticity. Now, a paper reveals that it is easier to alter the cognitive activity through transcranial magnetic stimulation (TMS) in people with a particular variant for the BDNF gene.
Chance of “Pathogenic” Genetic Variant Causing Disease Is Relatively Low content piece image
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Chance of “Pathogenic” Genetic Variant Causing Disease Is Relatively Low

Researchers have discovered that the chance a pathogenic genetic variant may actually cause a disease is about 7%, but some variants are linked to a wide range of risks for disease.
Faulty <i>BRCA</i> Genes and Risk of Developing Prostate and Pancreatic Cancers content piece image
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Faulty BRCA Genes and Risk of Developing Prostate and Pancreatic Cancers

Research has provided evidence that BRCA1 and BRCA2 are linked to several other cancers.
New Diagnostic Test Can Identify Genetic Sources of Mitochondrial Disease content piece image
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New Diagnostic Test Can Identify Genetic Sources of Mitochondrial Disease

A new diagnostic test has been designed to detect single nucleotide variants as well as large-scale deletions in the mitochondrial genome.
How To Land Therapeutic Genes Safely in the Human Genome content piece image
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How To Land Therapeutic Genes Safely in the Human Genome

Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called “genomic safe harbors (GSHs).”
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