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New Gene Editing Proteins Found Outside of CRISPR Systems
Scientists at MIT’s McGovern Institute and the Broad Institute of MIT and Harvard have discovered a new class of programmable DNA modifying systems called OMEGAs (Obligate Mobile Element Guided Activity), which may naturally be involved in shuffling small bits of DNA throughout bacterial genomes.
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Drugs That Mimic Effects of Cigarette Smoke Suppress ACE2 Expression in Cells
A team of scientists shows that treatment with AHR agonists decreases expression of ACE2 via AHR activation, reducing the ability of SARS-CoV-2 to enter the cell.
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Gut Cell Atlas Will Transform Research Into Intestinal Diseases
A new large-scale study mapped the cells in the human gut from early development through to adulthood, creating the most comprehensive Cell Atlas of the Gut to date.
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Cellular Blueprint of Multiple Sclerosis Lesions Created
Using brain tissue from humans, researchers at the National Institutes of Health’s National Institute of Neurological Disorders and Stroke built a detailed cellular map of chronic MS lesions, identifying genes that play a critical role in lesion repair and revealing potential new therapeutic targets for progressive MS.
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Shea Tree Genome Sequenced To Support Conservation Efforts
An international team of researchers led by the University of New Hampshire has sequenced the shea tree’s genome, providing a valuable resource for the strategic development of the species.
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Polygenic Risk Scores No Better Than Written Reports for Predicting Schizophrenia
Researchers went through the genetic and medical records of more than 8,000 schizophrenia patients. They found that a tool commonly used in research for evaluating a person’s genetic risk for a disease, called a polygenic risk score, was no better at predicting the outcome of a patient’s disease over time than written reports.
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Artificial Cells Mimic Vital Functions of Biological Cells
Researchers have developed artificial cell-like structures using inorganic matter that autonomously ingest, process, and push out material—recreating an essential function of living cells.
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Despite Years of Inbreeding, Kākāpō Are in Good Genetic Health
A genome sequencing study of the kākāpō offers some surprisingly good news: despite 10,000 years of island isolation and inbreeding, the species appears to have lost potentially deleterious mutations rather than accumulating them.
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Plants Developed That Act as Organic Pollutant Monitors
Researchers have successfully developed plants that can be used to detect organic pollutants, such as polychlorinated biphenyls and endocrine-disrupting chemicals, which contaminate soil and water.
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Population of Treatment-Resistant Cells Identified in Prostate Cancer Samples
Researchers have identified a specific population of treatment-resistant cells that was present in prostate cancer samples prior to treatment and persisted when subjected to treatment.
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