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New Gene Editing Proteins Found Outside of CRISPR Systems

Scientists at MIT’s McGovern Institute and the Broad Institute of MIT and Harvard have discovered a new class of programmable DNA modifying systems called OMEGAs (Obligate Mobile Element Guided Activity), which may naturally be involved in shuffling small bits of DNA throughout bacterial genomes.
Drugs That Mimic Effects of Cigarette Smoke Suppress ACE2 Expression in Cells content piece image
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Drugs That Mimic Effects of Cigarette Smoke Suppress ACE2 Expression in Cells

A team of scientists shows that treatment with AHR agonists decreases expression of ACE2 via AHR activation, reducing the ability of SARS-CoV-2 to enter the cell.
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Gut Cell Atlas Will Transform Research Into Intestinal Diseases

A new large-scale study mapped the cells in the human gut from early development through to adulthood, creating the most comprehensive Cell Atlas of the Gut to date.
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Cellular Blueprint of Multiple Sclerosis Lesions Created

Using brain tissue from humans, researchers at the National Institutes of Health’s National Institute of Neurological Disorders and Stroke built a detailed cellular map of chronic MS lesions, identifying genes that play a critical role in lesion repair and revealing potential new therapeutic targets for progressive MS.
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Shea Tree Genome Sequenced To Support Conservation Efforts

An international team of researchers led by the University of New Hampshire has sequenced the shea tree’s genome, providing a valuable resource for the strategic development of the species.
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Polygenic Risk Scores No Better Than Written Reports for Predicting Schizophrenia

Researchers went through the genetic and medical records of more than 8,000 schizophrenia patients. They found that a tool commonly used in research for evaluating a person’s genetic risk for a disease, called a polygenic risk score, was no better at predicting the outcome of a patient’s disease over time than written reports.
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Artificial Cells Mimic Vital Functions of Biological Cells

Researchers have developed artificial cell-like structures using inorganic matter that autonomously ingest, process, and push out material—recreating an essential function of living cells.
Despite Years of Inbreeding, Kākāpō Are in Good Genetic Health content piece image
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Despite Years of Inbreeding, Kākāpō Are in Good Genetic Health

A genome sequencing study of the kākāpō offers some surprisingly good news: despite 10,000 years of island isolation and inbreeding, the species appears to have lost potentially deleterious mutations rather than accumulating them.
Plants Developed That Act as Organic Pollutant Monitors content piece image
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Plants Developed That Act as Organic Pollutant Monitors

Researchers have successfully developed plants that can be used to detect organic pollutants, such as polychlorinated biphenyls and endocrine-disrupting chemicals, which contaminate soil and water.
Population of Treatment-Resistant Cells Identified in Prostate Cancer Samples content piece image
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Population of Treatment-Resistant Cells Identified in Prostate Cancer Samples

Researchers have identified a specific population of treatment-resistant cells that was present in prostate cancer samples prior to treatment and persisted when subjected to treatment.
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