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How Human Kidneys Form Their Filtering Units
Only nature possesses the complete set of blueprints for building a kidney. But scientists have conducted a comprehensive analysis of how kidneys form their filtering units, known as nephrons.
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Moderna Launches Trial of mRNA Vaccine for Methylmalonic Acidemia
The first patient has been dosed in a Phase 1/2 study of the investigational mRNA therapeutic for methylmalonic acidemia, a life-threatening, inherited metabolic disorder.
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Positive Impact of Restoring Hormone Levels in Neutered Dogs
A case study has given the first report of hormone restoration therapy for a dog suffering from diverse physical and psychological symptoms following castration. Treatment resulted in improved mobility and reduced anxiety.
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Key Protein Helps Sperm Do Their Job in a Timely Fashion
A team of researchers at University of California San Diego School of Medicine detail how GIV/Girdin, a ubiquitous signaling molecule plays a critical role in male fertility.
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Parent’s Genes Can Influence Their Child’s Educational Success
The genes a person inherits directly are most likely to contribute to their achievements in education. But parent genes that aren’t directly inherited, yet have still shaped parents’ own education levels and subsequently influenced the lifestyle and family environment they provide for their children, are also important and can affect how well a person does at school and beyond.
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Cardiovascular Disease Testing in Children Presents Unique Challenges
Cardiovascular genetic testing in children presents unique challenges, requiring pre- and post-test counseling with an individualized approach for families, ideally with the involvement of a specialized interdisciplinary team, according to the American Heart Association.
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T-Cell Profiling Identifies Important Metrics in Fighting SARS-CoV-2
Researchers have produced a precise profile of the T cells that respond to SARS-CoV-2 and described them at various stages of the illness. This novel methodological approach may in the future also help to assess the efficacy of SARS-CoV-2 vaccines or in the development of T cell-based treatments for serious cases.
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Rare Autoinflammatory Disease Can Be Treated With Existing FDA-Approved Drug
The absence of a protein that activates the body’s antiviral defenses can cause a rare rheumatoid-like autoinflammatory condition called TBK1, which is treatable with an existing FDA-approved drug.
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Circular RNA Shown To Inhibit Metastasis of Gastric Cancer
Researchers carried out gastric cancer circRNA profiling and identified circURI1 as having higher expression in gastric cancer compared to healthy tissues. They also discovered that circURI1 inhibited cell migration and invasion in vitro and gastric cancer metastasis in vivo.
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CRISPR Screening Uncovers New Therapeutic Target for Leukemia
A CRISPR screening tool has been used to identify a new therapeutic target to treat acute myeloid leukemia (AML) that may have fewer side effects than current approaches.
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