Bioethics Council Rules Heritable Genome Editing "Ethically Acceptable" In Certain CircumstancesNews
A leading UK bioethics advisory body has weighed in on the debate around human genetic modification, concluding that heritable genome editing – modifying the DNA of an egg, sperm or embryo with changes that will be passed on to future generations – could be ‘morally permissible’ in humans, provided key ethical tests are met.
Hay Fever Risk Genes Overlap with Autoimmune DiseaseNews
In a large international study involving almost 900,000 participants, researchers from the University of Copenhagen and COPSAC have found new risk genes for hay fever. It is the largest genetic study so far on this type of allergy, which affects millions of people around the world.READ MORE
ExPecto Patronum! Magical Machine Learning Tool Summons DNA Dark Matter DataNews
A new machine learning framework, dubbed ExPecto, can predict the effects of mutations in the so-called “dark matter” regions of the human genome. ExPecto pinpoints how mutations can disrupt the way genes turn on and off throughout your body.
CRISPR Causes More Genome Damage Than First ThoughtNews
Researchers have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. These results create safety implications for gene therapies using CRISPR/Cas9 in the future as the unexpected damage could lead to dangerous changes in some cells.
Sugarcane, the last unsequenced major cultivated plant, has had its genome decoded. Overcoming the sugarcane genome's extreme complexity, the research means it will now be possible to "modernize" the methods used to breed sugarcane varieties.
The rise of genomics, the shift from considering genes singly to collectively, is adding a new dimension to medical care. A new computational tool combines multiple types of genomic information to make stronger predictions about what genomic features are associated with specific drug responses.
Researchers at the Centre for Genomic Regulation (CRG) in Barcelona have developed a new method to systematically identify genes contributing to heritable cancer risk. Their work, which is published in Nature Communications, is a success story for data sharing and openness in science. A small team of three researchers identified new cancer genes only using publicly available data.READ MORE
Alternative splicing is a cellular mechanism that allows cells to produce many different proteins from a single gene. Researchers have shown that this process is key to the maintenance of skeletal muscle, providing insights into muscle mass loss in aging and chronic disease.READ MORE
A team of University of Konstanz biologists led by Professor Axel Meyer shows that evolutionary outcomes can be predicted: In a new publication in the journal “Evolution Letters”, they are able to identify some of the factors that contribute to recurrent patterns of diversity and similarity in cichlids.
A study in mice has exploited the power and potential of the CRISPR gene editing technique to engineer cancer cells that hunt down and attack their tumor of origin. The research could lead to promising therapies for different types of cancer.
Leeches are still used in modern medicine, and knowledge about their anticoagulants is important in many ways, from rodent control to understanding host-parasite relationships. A recent study expands our knowledge about the diversity of anticoagulants in two families of leeches.READ MORE
Researchers at the University of Arizona College of Medicine – Phoenix are attempting to create a better diagnostic test for radiation exposure that potentially could save thousands of lives.READ MORE
Antioxidants are molecules that counteract the damage to our bodies from harmful products of normal cells called reactive oxygen species (ROS). Now, research has found that a protein called ATM can sense the presence of ROS and responds by sounding the alarm to trigger the production of antioxidants.READ MORE