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Researchers have shown that the calcium channel blocker (CCB), mibefradil, inhibits DNA repair independent of its CCB activity. The findings could lead to a new class of mibefradil-based DNA repair inhibitors for glioblastoma.

An in vitro study demonstrates how fungi and bacteria can activate genes linked to head and neck tumors. The researchers revealed that the metabolism of biofilms stimulates cancer cells by favoring specific cell signaling pathways associated with the development of tumors and drug resistance.

To improve the development of new saliva-based diagnostic tests and personalized medicine, the National Institute of Dental and Craniofacial Research has supported the development of the Human Salivary Proteome Wiki, the first public platform that catalogs and curates data on each of the thousands of proteins within our saliva.

The team discovered that the modern human genome undergoes mutation which makes the adenylosuccinate lyase enzyme less stable, leading to a decrease in purine synthesis. This mutation did not occur in Neanderthals, so the scientists believe that it affected metabolism in brain tissues and thereby strongly contributed to modern humans evolving into a separate species.

A rich community of previously undescribed microbes exists in the transition layer between the deep water of the Red Sea and the surface of brine pools, discovered during the Five Deeps Expedition.

Researchers at Lund University in Sweden have developed an algorithm that combines data from a simple blood test and brief memory tests, to predict with great accuracy who will develop Alzheimer's disease in the future.

Researchers from ETH Zurich and the University of Zurich deciphered the cellular mechanisms through which tendons can adapt to mechanical stresses. People who carry a certain variant of a gene that is key to this mechanism show improved jumping performance.

New research shows that concentrations of the toxic element mercury in rivers and fjords connected to the Greenland Ice Sheet are comparable to rivers in industrial China, an unexpected finding that is raising questions about the effects of glacial melting in an area that is a major exporter of seafood.

The results from a clinical trial using optogenetics to treat a patient with retinitis pigmentosae show that the therapy was able to partially restore visual function.

Scientists have used structural biology techniques to map how important classes of neutralizing antibodies bind to the original strain of SARS-CoV-2, and how the process is disrupted by mutations found in new variants.