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Researchers have described a new gene-editing technology called CRISPRoff that allows researchers to control gene expression with high specificity while leaving the sequence of the DNA unchanged. The method is stable enough to be inherited through hundreds of cell divisions, and is also fully reversible.

A study has revealed that the pH of milk should be considered in looking at ways to improve sheep's milk cheese production and yield.

Researchers have unveiled a novel feature of COVID-19 immunity, which could have implications for future therapies. The study points to the involvement of Interleukin 33 when immune cells encounter Sars-CoV-2 for a second time.

Scientists have analyzed how microbes in the gut process the plant-based, sulfur-containing sugar sulfoquinovose. The study discovered that specialized bacteria cooperate in the utilization of the sulfosugar, producing hydrogen sulfide, known to have positive and negative effects on health.

Current single-cell transcriptomic methods put cells under stress, limiting accurate investigations. Scientists have now created the ACME method which fixes cells immediately, without cell dissociation, allowing for more accurate investigation.

Researchers have used human genetics in a new study and the findings suggest researchers should prioritize clinical trials of drugs that target the proteins IFNAR2 and ACE2 to manage COVID-19 in its early stages.

Preclinical research using cell lines, genetic mouse models and human pancreatic tumor tissue samples has identified the transcription factor CREB1 as a potential therapeutic target for the treatment of pancreatic cancer.

A new study published in Molecular Psychiatry outlines the development of an RNA biomarker-based blood test for distinguishing how severe an individual's depression is, determining the risk of a patient developing severe depression in the future, determining the risk of future bipolar disorder and tailored medication choices for patients.

Researchers have used a large-scale human genetics study to identify drug targets important for managing COVID-19 in its early stages.

Scientists have reported the full assembly of human chromosome 8. While on the outside this chromosome looks typical, being neither short nor long or distinctive, its DNA content and arrangement are of interest in primate and human evolution, in several immune and developmental disorders, and in chromosome sequencing structure and function generally.