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Antibiotic Effectiveness Hampered by Our Own Immune System
Research has revealed that a molecule produced by the human immune system can severely diminish the potency of certain antibiotics. This may explain why antibiotics effective in laboratory settings can be less effective at clearing infections in humans.
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“Intriguing” Protein Complex May Hold the Key To Treating Chromosomal Disorders
The process of DNA repair involves a complex interplay between several gene pathways and proteins. One such pathway is the "Fanconi anemia (FA) pathway,". FANCM, a component of this pathway, interacts with another component called MHF in order to function. The loss of the FANCM-MHF complex can result in chromosomal instabilities that can lead to diseases. Scientists have explored the crystalline structure of the FANCM-MHF complex using X-ray diffraction techniques.
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How Environmental Exposures Before Conception May Impact Fetal Development
A new report published in Proceedings of the National Academy of Sciences suggests older age and alcohol consumption in the year leading up to conception also may have an impact by epigenetically altering a specific gene during development of human eggs, or oocytes.
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Immune Receptor Protein Could Offer Autoimmune Disease Treatment Target
Rheumatoid arthritis is an autoimmune disease in which immune cells erroneously attack the body's own joint components and proteins, causing painful inflammation and even the destruction of bone. Scientists have now taken a step toward understanding and, potentially, treating rheumatoid arthritis better, with the identification of genes that were overexpressed in various mouse models of arthritis.
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“Genome Scalpel” Can Trim Microalgal Genomes Rapidly and Creatively
Researchers from the Qingdao Institute of BioEnergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences (CAS) have stripped hundred-kilobase genome from a type of oil-producing microalgae, knocking out genes non-essential for it to function. By doing so, they have created a "genome scalpel" that can trim microalgal genomes rapidly and creatively.
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Solving Nucleic Acid Synthesis Mystery May Help To Design New Antivirals
Scientists have solved the mystery of how living organisms distinguish RNA and DNA building blocks during gene expression, paving the way for the design of new antiviral drugs.
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"Giraffe-Type" Gene-Edited Mice Are Resistant to High Blood Pressure
A new study has found that, when inserted into mice, giraffe genes confer resistance to high blood pressure.
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UK SARS-CoV-2 Variant Spread Rapidly in Care Homes
According to a study, the UK variant of SARS-CoV-2 spread rapidly in care homes in England in November and December last year, broadly reflecting its spread in the general population.
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First Evidence Pathogenic Fungus Can Thrive Outside Its Host
For the first time, researchers have isolated the fungus Candida auris from a sandy beach and tidal swamp in a remote coastal wetland ecosystem. The discovery represents the first evidence that the pathogen thrives in a natural environment and is not limited to mammalian hosts.
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Could Industrial Pollution Exposure Be Contributing to Increase in Cryptorchidism?
According to a study, environmental pollution from industries such as coal mining and metal works may play a role in the increasing numbers of boys born with undescended testicles.
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