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Insight Into a Key Mechanism Involved in Cancer Metastasis
Breast cancer is harmful enough on its own, but when cancer cells begin to metastasize it becomes much more difficult to treat. In a new study, researchers take a closer look at a key mechanism, epithelial-to-mesenchymal transition, and explore its role in metastasis.
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Combining Environmental and Public Health Data Could Help Allergy Sufferers
New research, that brings healthcare data together with ground-breaking ecological techniques, could set a roadmap for refining pollen forecasts in the future.
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Using Whole Genome Sequencing To Guide Blood Cancer Treatment
A new study shows that whole genome sequencing is often more accurate than conventional genetic tests and could help determine the treatment for blood cancers such as acute myeloid leukemia and myelodysplastic syndrome.
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First Study of the Human Placenta’s Genomic Architecture
In the first study of the genomic architecture of the human placenta, scientists at the Wellcome Sanger Institute, the University of Cambridge and their collaborators have confirmed that the normal structure of the placenta is different to any other human organ and resembles that of a tumour, harbouring many of the same genetic mutations found in childhood cancers.
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B.1.1.7 COVID-19 Variant Associated With a Significantly Higher Mortality Rate
A study has shown that a SARS-CoV-2 variant, B.1.1.7, is associated with a significantly higher mortality rate compared to previously circulating strains.
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Scientists Develop "Non-Permanent" Gene Therapy for Pain Treatment
A new study published in Science Translational Medicine outlines the work of researchers that have developed a novel gene therapy using CRISPR-based gene editing to achieve pain relief in mice.
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Getting Polygenic Risk Scores Into the Clinic
Polygenic risk scores represent a new approach for assessing a person's inherited risk for certain diseases such as Type 2 diabetes or coronary heart disease. A set of new guidelines for reporting polygenic risk scores in a consistent way, and the launch of an open database for these scores could make the data more useful in clinical care.
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Rare Gene Mutations Have Big Impact on Schizophrenia Pathology
Schizophrenia is a neurodevelopmental disorder that produces hallucinations, delusions, and other cognitive disturbances. A new study now shows that "somatic" gene mutations in brain cells could account for some neuropathology of Schizophrenia.
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Gene Sensor Shows Why Patients Decline After Stopping Alzheimer's Drugs
Scientists have developed a method to monitor transmissions within the brain, and their creation has offered an explanation for why Alzheimer’s drugs have limited effectiveness and why patients get much worse after going off of them.
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Rare Cell Types in the Upper Gastrointestinal Tract Identified
Researchers have identified a rare cell type in the gastrointestinal tract that is likely responsible for the secretion of high volumes of water in humans. This cell type provides a link to gastrointestinal defects in patients with cystic fibrosis.
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