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CRISPRi Screens Reveal Sources of Metabolic Robustness in <i>E. coli</i> content piece image
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CRISPRi Screens Reveal Sources of Metabolic Robustness in E. coli

A massively parallel CRISPRi screen demonstrated that E. coli metabolism is very robust against knockdowns of enzymes, and multi-omics data revealed the mechanisms behind it. In the future, the researchers want to apply this knowledge to build better models of metabolism, which enable rational-design of industrial microbes.
Decoding the Desert Locust Genome Could Help Combat the Notorious Pest content piece image
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Decoding the Desert Locust Genome Could Help Combat the Notorious Pest

A study deciphering the genetic material of the desert locust could help combat the crop-ravaging behaviour of an insect pest which currently exacerbates a hunger crisis.
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Using Plants To Synthesize Medicinal Compounds

New work from an international team of scientists including Carnegie’s Sue Rhee reveals a gene responsible for anthraquinone synthesis in plants. Their findings could help scientists cultivate a plant-based mechanism for harvesting these useful compounds in bulk quantities.
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“Turbo Charging” the Genetic Stocks Contained in the World’s Seed Banks

New research has been published that predicts traits in corn-based on genomics and data analytics.
Metal-Organic Frameworks Successfully Deliver CRISPR/Cas9 Into Human Cancer Cells content piece image
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Metal-Organic Frameworks Successfully Deliver CRISPR/Cas9 Into Human Cancer Cells

Researchers used metal-organic frameworks (MOFs) enhanced with a green tea phytochemical coating to target human prostate cancer cells for the first time.
Folding of SARS-CoV2 Genome Reveals Drug Targets content piece image
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Folding of SARS-CoV2 Genome Reveals Drug Targets

Research alliance has observed the RNA folding structures of the SARS-CoV2 genome with which the virus controls the infection process.
ChIP-Seq May Have Been Quantitative All Along content piece image
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ChIP-Seq May Have Been Quantitative All Along

ChIP-seq provides invaluable insights into the underpinnings of health and disease, it also faces a frustrating challenge, but its results are often viewed as qualitative rather than quantitative, making interpretation difficult. A recent report suggests that ChIP-seq may have been quantitative all along.
Plant Used in Chinese Medicine Has Evolved To Become Less Visible to Humans content piece image
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Plant Used in Chinese Medicine Has Evolved To Become Less Visible to Humans

Scientists found that Fritillaria delavayi plants, which live on rocky slopes of China's Hengduan mountains, match their backgrounds most closely in areas where they are heavily harvested.
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Uncovering the Inner Workings of a Key Cellular Machine Involved in Human Cancers

A team of scientists has discovered new functions of a key cellular machine that regulates gene packaging. This "machine" called BAF/PBAF is mutated in 20% of all human tumors, including pancreatic cancer, gastric cancer and melanoma.
Specific Oncogene Linked to the Spread of Triple-Negative Breast Cancer content piece image
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Specific Oncogene Linked to the Spread of Triple-Negative Breast Cancer

Researchers have identified a gene responsible for the spread of triple-negative breast cancer and developed a potential way to stop it.
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