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How the CRISPR Immune System Evolved
New research results shed new light on how CRISPR-Cas emerged early during the development of life on Earth, as well as how this immune system is constantly adapting to new challenges.
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Stem Cell-Based Screen Finds Potential Treatments for Vision Loss
Vision loss related to aging or inherited genetic disease is often caused by defects in the retinal pigment epithelium (RPE) in the eye. In a recent study, researchers used induced pluripotent stem cells (iPSCs) derived from the skin of healthy donors and of patients with retinitis pigmentosa to find drugs with the potential to enhance RPE phagocytosis.
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Springer Nature Announces New Open-Access Option for Journals
The publisher Springer Nature has shared its gold open-access (OA) options for Nature journals that will be introduced from January 2021. Whilst the initiative to move towards OA is positive news for its proponents, the considerable price tag attached is a worry.
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CRISPRi Screens Reveal Sources of Metabolic Robustness in E. coli
A massively parallel CRISPRi screen demonstrated that E. coli metabolism is very robust against knockdowns of enzymes, and multi-omics data revealed the mechanisms behind it. In the future, the researchers want to apply this knowledge to build better models of metabolism, which enable rational-design of industrial microbes.
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Decoding the Desert Locust Genome Could Help Combat the Notorious Pest
A study deciphering the genetic material of the desert locust could help combat the crop-ravaging behaviour of an insect pest which currently exacerbates a hunger crisis.
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Using Plants To Synthesize Medicinal Compounds
New work from an international team of scientists including Carnegie’s Sue Rhee reveals a gene responsible for anthraquinone synthesis in plants. Their findings could help scientists cultivate a plant-based mechanism for harvesting these useful compounds in bulk quantities.
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“Turbo Charging” the Genetic Stocks Contained in the World’s Seed Banks
New research has been published that predicts traits in corn-based on genomics and data analytics.
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Metal-Organic Frameworks Successfully Deliver CRISPR/Cas9 Into Human Cancer Cells
Researchers used metal-organic frameworks (MOFs) enhanced with a green tea phytochemical coating to target human prostate cancer cells for the first time.
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Folding of SARS-CoV2 Genome Reveals Drug Targets
Research alliance has observed the RNA folding structures of the SARS-CoV2 genome with which the virus controls the infection process.
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ChIP-Seq May Have Been Quantitative All Along
ChIP-seq provides invaluable insights into the underpinnings of health and disease, it also faces a frustrating challenge, but its results are often viewed as qualitative rather than quantitative, making interpretation difficult. A recent report suggests that ChIP-seq may have been quantitative all along.
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