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A New Type of Meta-DNA Structure
A team of researchers has announced the creation of a new type of meta-DNA structures that will open up the fields of optoelectronics (including information storage and encryption) as well as synthetic biology.
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Dorsal Rooth Ganglion Pathology Associated With AAV Gene Therapy in Animal Model
A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology. There were no clinical effects.
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Cellular Roadmaps Predict Body's Coronavirus Vulnerability
New Cornell research has developed potential roadmaps for how SARS-CoV-2 infects the body's organs, and identified what molecular factors could help facilitate or restrict infection.
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Editing the Immune Response To Aid the Delivery of Gene Therapy Cargo
Researchers at the University of Pittsburgh created a system that uses CRISPR in a different way. Their system briefly suppresses genes that are related to AAV antibody production so the virus can deliver its cargo unimpeded. These results published in Nature Cell Biology.
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Ability To Digest Milk Spread “Quickly” Through Europe
The ability for humans to digest milk as adults has altered our dietary habits and societies for centuries. But when and how that ability - known as lactase persistence or lactose tolerance - occurred and became established is up for debate.
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Mummy Conservation Learns Lessons From 400-Year-Old Chamois Remains
A chamois had been protected by a glacier for 400 years and only recently released as the ice receded. Due to their age and state of preservation, the remains are in fact a perfect simulant of a human mummy and will allow researchers to improve the conservation techniques of ice mummies all over the world while determining methods for the safeguarding of ancient DNA.
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A New Target for Congenital Blindness Gene Therapy Is in Sight
Retinitis pigmentosa is the most prevalent form of congenital blindness. Using a retinitis pigmentosa mouse model, LMU researchers have now shown that targeted activation of genes of similar function can compensate for the primary defect.
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New Algorithm Reveals How Tumors Evolve During Their Lifetime
A new algorithmic approach reveals individual tumors continue to evolve and remodel their genomes, and this occurs across a broad range of tumor types. Identifying changes that benefit tumors and help them metastasize could help with future treatments.
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Reprogramming Yeast To Become a Mini Drug Factory
Stanford engineers have genetically reprogrammed the cellular machinery of yeast to create microscopic factories that convert sugars and amino acids into plant-based drugs.
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T Cells Can Become Memory Cells Before Even Meeting Their Foe
Memory cells remember previously encountered pathogens and help the body to react quickly and strongly when exposed to them again. However, the developmental process of strong immune cells that make these memory cells in advance without having to encounter the pathogens has now been discovered.
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