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Finnish People’s Unique Genetic Makeup Offers Novel Insights Into Disease
A new study harnessed the unique genetic history of the people of Finland to identify variations in DNA that might predispose certain individuals to disease, whether or not they are Finnish themselves.
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Lung Cells Hustle to Repair Damaged DNA Post-influenza Attack
Scientists have identified one kind of lung cell that can hustle to repair its damaged DNA and survive an attack of the influenza A virus while other kinds of cells around it die in droves.
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A Step Closer to Understanding Neurodevelopmental Disorders
Scientists suspected a mutation in a complex of proteins could be the culprit for a group of rare genetic disorders. Now, researchers have identified the molecular mechanism linking this mutation with abnormal nervous system development, bringing science a step closer to understanding disorders such as Nicolaides-Baraitser syndrome and others.
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Glowing Cholesterol Gives Scientists a Glimpse of How to Fight Heart Disease
Researchers have developed the LipoGlo system, which used state-of-the-art genome engineering to tag ApoB with a glowing enzyme that's similar to the one that lights up fireflies.
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Viruses That Hid in Ancestor's DNA Are Waking Up
Researchers explain how viruses ended up in our DNA – and what puts them in the frame in unsolved diseases like multiple sclerosis.
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Capturing the Footprint of Viral Vector Gene Therapy
Building on a track record of developing adeno-associated viral (AAV) vectors as a groundbreaking clinical tool for gene therapy and gene editing, Children's Hospital of Philadelphia (CHOP) researchers report a more sensitive method for capturing the footprint of AAV vectors--a broad range of sites where the vectors transfer genetic material.
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Cigarette Smoke Makes MRSA Superbug More Antibiotic-resistant
Cigarette smoke can make MRSA bacterial strains more resistant to antibiotics, new research shows.
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Analyzing p53 Mutations in 10,000 Cancer Patients
Researchers shed light on how the TP53 gene becomes mutated and how those mutations can help predict clinical outlook.
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Genetic Vulnerability to Post-traumatic Stress Disorder in U.S. Veterans
A genome-wide association study (GWAS) and bioinformatic analysis of more than 165,000 U.S. veterans confirms a genetic vulnerability to post-traumatic stress disorder (PTSD), specifically noting abnormalities in stress hormone response and/or functioning of specific brain regions.
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Fish Shed Light on Limb-regeneration Secrets
Researchers are the first to study how gar and other fish regenerate entire fins. More importantly, the researchers focused on how they rebuild the endochondral bones within their fins, which are the equivalents of human arms and legs.
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