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Predicting Anti-Diabetes Drug Response Using Fat Cell Genetics
In a new study published in Cell Stem Cell, a team of researchers have demonstrated, using fat cells derived from human stem cells, that individual genetic variation can be used to predict whether the TZD rosiglitazone will produce the unwanted side effect of increasing cholesterol levels in certain individuals.
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Major Progress for Rare Autoimmune Syndrome Gene Therapy
This gene therapy is similar to the technique the lab has used against another immune disease—severe combined immune deficiency, also known as bubble baby disease.
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Genes Involved in Immune System Regulation Identified
Researchers have mapped the most important genes for controlling T helper cells, and identified new regulatory genes that could help scientists to develop new treatments to activate the immune system against infection or to attack tumour cells.
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Biomarker Links Cancer Progression to Genome Instability
A new Tel Aviv University study identifies elevated levels of a protein called ubiquilin-4 as a new biomarker for genome instability.
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Unique Role for tRNA-derived RNA Fragments in Parasites
A new molecular regulatory mechanism has been observed in unicellular parasites for the very first time. tRNA-derived fragments do not act as brakes in the cell apparatus, but as 'stimulants': they boost protein production after periods of stress.
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Antibiotic Resistance in the Environment Linked to Fecal Pollution
A new study indicates that fecal pollution can largely explain the increase in resistant bacteria often found in human-impacted environments.
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3D Genome Reveals How the Brain Detects Different Scents
Researchers have used advanced genomic tools to uncover an ingenious mechanism that underlies the brain’s ability to distinguish different smells.
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Microbial Metabolite of Berries Shows Anti-inflammatory Properties
A microbial metabolite, Urolithin A, derived from a compound found in berries and pomegranates, shows anti-inflammatory properties in mice offering potential for inflammatory bowel disease therapies.
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Maize Genome Analysis to Fuel Improvements in the World’s Most Important Grain
A new collaboration between industry and academia has successfully completed de novo genome assembly for the maize population, which involves 26 cultivars found in the United States. Maize is the world’s most important grain based on production volume, which makes it a particularly critical crop to understand in order to support growing global demands.
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Mutation Links Aggressive Prostate Cancer and Hereditary Breast Cancer
Researchers show that aggressive prostate cancer, one of the leading causes of cancer deaths in men, is associated with BRCA2 mutations, which are also linked to hereditary breast cancer, ovarian cancer and pancreas cancer, among others.
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