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Cellular Drivers of Painful Childhood Food Allergy Characterized
News   Apr 10, 2019

An eight-year hunt for the cells that drive an extreme childhood food allergy (eosinophilic esophagitis, EoE) has identified a potential new way to treat the disease while also raising questions about a dietary supplement often taken to reduce bowel inflammation.

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Mapping Tumor Immune Cell Populations Points to Immunotherapy Targets
News   Apr 10, 2019

Tumors are a complex mixture of many different cell types, including immune cells known collectively as tumor-infiltrating myeloid cells. These cells represent alternative targets for immunotherapy, but their role in tumors is still poorly understood. To shed light on this under-examined family of immune cells, researchers used single-cell sequencing to map the landscape of myeloid cells in tumors from patients with lung cancer.

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Famous p53 Gene Also Protects Against Birth Defects
News   Apr 10, 2019

New research has revealed how the famous tumour suppressor gene p53 is surprisingly critical for development of the neural tube in female embryos.

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Blood Test for Endometriosis Detects up to 9 in 10 Cases
News   Apr 10, 2019

A pioneering blood test that can detect up to 90% of cases of endometriosis looks for tiny DNA fragments in the blood, and could spare women needing to undergo keyhole surgery to diagnose the condition.

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CSI Meets Conservation
News   Apr 10, 2019

Wildlife detectives aiming to protect endangered species have long been hobbled by the near impossibility of collecting DNA samples from rare and elusive animals. Now, researchers have developed a method for extracting genetic clues quickly and cheaply from degraded and left-behind materials, such as feces, skin or saliva, and from food products suspected of containing endangered animals.

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History Unraveled As WW1 Cholera Genome Is Sequenced
News   Apr 10, 2019

The oldest publicly-available strain of the cholera-causing bacterial species, Vibrio cholerae, has had its genetic code read for the first time by researchers at the Wellcome Sanger Institute and their collaborators. The bacterium was isolated from a British soldier during World War One (WWI) and stored for over 100 years before being revived and sequenced.

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Creating Climate-friendly Cattle Farms
News   Apr 10, 2019

Researchers created the first dense molecular map of B. humidicola, a robust and environmentally friendly forage grass. They also pinpointed the candidate genes for the plant’s asexual reproductive mechanism, which is a huge asset for plant breeders.

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CpG Traffic Lights: Green Is Go for Gene Activity
News   Apr 10, 2019

A research team has identified reliable markers of gene activity. The discovery has potential for future applications in clinical practice.

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Ultrasound Control of Genes a Feasible Approach for Bone Regeneration
News   Apr 09, 2019

A new study marrying high-intensity focused ultrasound with genetically modified cells may spur bone and soft tissue regeneration.

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Global Microbial Signatures for Colorectal Cancer Established
News   Apr 09, 2019

Patients with colorectal cancer have the same consistent changes in the gut bacteria across continents, cultures, and diets.

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